PMID: 8581320Jan 1, 1995Paper

Cooliatoxin, the first toxin from Coolia monotis (Dinophyceae)

Natural Toxins
M J HolmesA W Hoy

Abstract

Coolia monotis is a benthic dinoflagellate previously thought to be non-toxic. We describe a new toxin, named cooliatoxin, purified from cultures of a strain of C. monotis isolated from Australia. Cooliatoxin is likely a mono-sulphated, polyether toxin (M = 1,062; i.p. LD50 = 1 mg/kg in mice) that induces hypothermia and respiratory failure in mice after a pronounced delay period during which there are no obvious signs of intoxication. These signs in mice are similar to those reported for the shellfish toxin named yessotoxin and the molecular weight of cooliatoxin corresponds to the mono-sulphated form of yessotoxin, suggesting that cooliatoxin may be an analogue of yessotoxin. Cooliatoxin has no effect on the mouse phrenic nerve or diaphragm musculature in vitro but causes initial stimulation and subsequent block of unmylenated nerves in vitro. In isolated guinea pig left atria, cooliatoxin (above 20 nm) induced a slow developing concentration dependent sustained inotropic response. Propranolol or tetrodotoxin reversed the positive inotropic effects, indicating that the majority of the cooliatoxin induced response was mediated by stimulation of nerves associated with the atrial musculature, resulting in the release of noradren...Continue Reading

References

May 1, 1979·The Journal of Pharmacy and Pharmacology·L Molinengo
Aug 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·R J Lewis, M Sellin
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·M MurataJ W Daly
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·R J LewisM M Sheil
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·M J HolmesN C Gillespie
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·M J HolmesN C Gillespie
Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R J Lewis, R Endean
Jan 1, 1984·Toxicon : Official Journal of the International Society on Toxinology·R J Lewis, R Endean
Apr 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·R J Lewis, A W Hoy

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Citations

Dec 10, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·K S Rein, J Borrone
Aug 30, 2008·Marine Drugs·Beatriz PazJosé J Fernández
May 1, 2010·Toxins·Lydia Ignatiades, Olympia Gotsis-Skretas
Jun 2, 2009·Toxicon : Official Journal of the International Society on Toxinology·Lesley L RhodesMarie-Yasmine Bottein
Nov 21, 2009·Toxicon : Official Journal of the International Society on Toxinology·Humberto J DominguezJosé J Fernández
Dec 1, 2013·Journal of Phycology·Frances M Van DolahRossella Pistocchi
Jul 11, 2020·Scientific Reports·Li Keat LeePo Teen Lim
Apr 8, 2020·Environmental Toxicology and Pharmacology·Ana T VarelaAntónio J Moreno
Aug 22, 2006·Toxicon : Official Journal of the International Society on Toxinology·Joanne S M Yoshikawa Ebesu, Yoshitsugi Hokama

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