PMID: 11903504Mar 21, 2002Paper

Cooling-induced gastrointestinal smooth muscle contractions in the rat

Fundamental & Clinical Pharmacology
S M Mustafa, O Thulesius

Abstract

The aim of this study was to assess the effect of cooling on smooth muscle contraction in various parts of the gastrointestinal tract (esophagus, stomach, duodenum, jejunum and colon) and to investigate the basic mechanism underlying cooling-induced (CIC) tonic and rhythmic contractions. Recordings of isometric tension from smooth muscle strips of different parts of the rat gastrointestinal tract were performed using organ-bath techniques, and stepwise cooling was applied. Cooling was tested before and after the addition of various standard agents interfering with known neurogenic (autonomic blockers, tetrodotoxin, capsaicin) and myogenic mechanisms of contraction (calcium channel blockers, Sarcoplasmatic and Ca2+-ATPase pump inhibitors). Step-wise cooling (37 degrees C to 5 degrees C) of all gastrointestinal smooth muscle preparations induced reproducible graded tonic contractions, inversely proportional to temperature. CIC was most pronounced in the jejunum. Cooling abolished rhythmic smooth muscle activity. CIC was not dependent on a neural mechanism nor the release of neurotransmitters, but linked to translocation of calcium. It was reduced by incubation in Ca2+-free solution. Blockage of the Ca2+-ATPase pump, which inhibit...Continue Reading

References

Jun 12, 1979·Pflügers Archiv : European journal of physiology·B N GuptaH Hensel
May 1, 1989·Clinical and Experimental Pharmacology & Physiology·W Y Chen
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Nov 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·M K ParkJ L Robotham
Jan 1, 1981·Physiological Reviews·F Schuurmans Stekhoven, S L Bonting
Apr 24, 1981·European Journal of Pharmacology·R Deth, C Lynch
Dec 1, 1984·Pflügers Archiv : European journal of physiology·D F Cottrell
Sep 1, 1983·British Journal of Pharmacology·R A Nayler, M P Sparrow
Sep 1, 1993·Circulation·S Ballin, C Louis

❮ Previous
Next ❯

Citations

Oct 30, 2012·Journal of Neurogastroenterology and Motility·Yutang RenMin Chang
Jan 21, 2006·The Journal of Sexual Medicine·Ahmed AteyahHatem Saad El-Den
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Seham Mustafa, Olav Thulesius
Apr 10, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yunping LiKathleen G Morgan
May 17, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·A AltomareS Filippi
Mar 24, 2018·International Urology and Nephrology·Seham Mustafa
Sep 24, 2005·Journal of Applied Physiology·Fumio YamazakiJohn M Johnson
Jan 18, 2021·Journal of Thermal Biology·Seham Mustafa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Canadian Journal of Physiology and Pharmacology
Seham Mustafa, O Thulesius
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
S M MustafaK I Williams
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
S M MustafaK I Williams
Respiration; International Review of Thoracic Diseases
G Santacana, W Y Chen
© 2022 Meta ULC. All rights reserved