Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies.

Neuron
Peter Petersen, György Buzsáki

Abstract

Hippocampal theta oscillations coordinate neuronal firing to support memory and spatial navigation. The medial septum (MS) is critical in theta generation by two possible mechanisms: either a unitary "pacemaker" timing signal is imposed on the hippocampal system, or it may assist in organizing target subcircuits within the phase space of theta oscillations. We used temperature manipulation of the MS to test these models. Cooling of the MS reduced both theta frequency and power and was associated with an enhanced incidence of errors in a spatial navigation task, but it did not affect spatial correlates of neurons. MS cooling decreased theta frequency oscillations of place cells and reduced distance-time compression but preserved distance-phase compression of place field sequences within the theta cycle. Thus, the septum is critical for sustaining precise theta phase coordination of cell assemblies in the hippocampal system, a mechanism needed for spatial memory.

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Citations

Jun 28, 2020·Nature Reviews. Neuroscience·Sian Lewis
Dec 8, 2020·Frontiers in Behavioral Neuroscience·Daniel de Castro MedeirosMárcio Flávio Dutra Moraes
Apr 10, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yiyao ZhangGyörgy Buzsáki
May 13, 2021·Cell·Salman E QasimJoshua Jacobs
May 11, 2021·Frontiers in Systems Neuroscience·Yuchen ZhouAndrew P Maurer
Jun 26, 2021·Neuron·Arkarup BanerjeeMichael A Long
Jul 27, 2021·Frontiers in Neural Circuits·Yuichi TakeuchiAntal Berényi
Jul 8, 2021·Nature Reviews. Neuroscience·Marielena Sosa, Lisa M Giocomo
Aug 10, 2021·Frontiers in Neural Circuits·Petra Mocellin, Sanja Mikulovic
Sep 17, 2021·Learning & Memory·Zachary M GemzikAmy L Griffin
Oct 15, 2021·ELife·Jennifer C Robinson, Mark P Brandon
Sep 19, 2021·Annual Review of Psychology·György BuzsákiLila Davachi

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