PMID: 8985864Dec 1, 1996Paper

Cooling-specific spinothalamic neurons in the monkey

Journal of Neurophysiology
J O Dostrovsky, A D Craig

Abstract

1. Little is known concerning the processing of innocuous thermoreceptive information in the CNS of the monkey. The aim of the present study was to confirm the prediction, based on recent studies in cat and monkey, that there must be a prominent spinothalamic (STT) projection of cooling-specific spinal cord lamina I neurons to the posterior part of the ventral medial nucleus (VMpo) of the monkey thalamus. 2. Experiments were performed on four cynomolgus monkeys anesthetized with pentobarbital sodium. A detailed mapping of somatosensory thalamus was performed in each animal, and VMpo was identified by recordings from clusters of thermoreceptive-specific and nociceptive-specific (NS) neurons. Stimulating electrodes were then implanted in VMpo. Tungsten microelectrodes were used to record the responses of neurons in the superficial dorsal horn of the lumbosacral spinal cord. 3. Many spontaneously active lamina I neurons were found that were inhibited by radiant warming and that responded to innocuous cooling of the hindpaw. These cooling-specific (COLD) neurons were excited by small temperature drops below skin temperature and increased their discharge with decreasing skin temperature. They were not excited by thermally neutral me...Continue Reading

Citations

Apr 14, 1999·Journal of Neurophysiology·K D DavisJ O Dostrovsky
Apr 12, 2000·Journal of Neurophysiology·H BesterJ F Bernard
Jan 11, 2003·Journal of Neurophysiology·G D IannettiG Cruccu
Aug 30, 2005·The Journal of Comparative Neurology·Xiao Hong YuYves De Koninck
Mar 20, 2009·The Journal of Comparative Neurology·L AlmarestaniA Ribeiro-da-Silva
Jul 19, 2000·Journal of Neurophysiology·A V ApkarianL R Airapetian
Apr 9, 1999·Nature Neuroscience·Z S HanA D Craig
Jan 29, 2000·Nature Neuroscience·A D CraigE M Reiman
Apr 18, 2009·British Journal of Pharmacology·Paul J WrigleyChristopher W Vaughan
Aug 26, 2010·Somatosensory & Motor Research·You-Yin ChenRen-Shyan Liu
Nov 23, 2012·The Journal of Comparative Neurology·Abeer W Saeed, Alfredo Ribeiro-da-Silva
Apr 9, 1999·Nature Neuroscience·E R Perl
Apr 29, 2006·Pain·Takeshi TsujiRyusuke Kakigi
Sep 14, 2004·Journal of Neurobiology·Barry G Green
Apr 23, 2005·Journal of Neurophysiology·Xijing Zhang, Glenn J Giesler
Jun 2, 2005·Journal of Neurophysiology·Shin-Ichi Ito, A D Craig
Jul 18, 2009·Experimental Brain Research·Ruth DefrinLars Arendt-Nielsen
Nov 28, 2009·European Journal of Pain : EJP·Richard HulseLucy F Donaldson
Dec 4, 2001·The Journal of Physiology·D Andrew, A D Craig
Jul 21, 2007·The Journal of Comparative Neurology·L AlmarestaniA Ribeiro-da-Silva
Mar 26, 2008·Journal of Dental Research·K KuboY Kaneko

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