Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins

Genetics and Molecular Biology
Namrata KumarBennett Van Houten

Abstract

Base and nucleotide excision repair (BER and NER) pathways are normally associated with removal of specific types of DNA damage: small base modifications (such as those induced by DNA oxidation) and bulky DNA lesions (such as those induced by ultraviolet or chemical carcinogens), respectively. However, growing evidence indicates that this scenario is much more complex and these pathways exchange proteins and cooperate with each other in the repair of specific lesions. In this review, we highlight studies discussing the involvement of NER in the repair of DNA damage induced by oxidative stress, and BER participating in the removal of bulky adducts on DNA. Adding to this complexity, UVA light experiments revealed that oxidative stress also causes protein oxidation, directly affecting proteins involved in both NER and BER. This reduces the cell's ability to repair DNA damage with deleterious implications to the cells, such as mutagenesis and cell death, and to the organisms, such as cancer and aging. Finally, an interactome of NER and BER proteins is presented, showing the strong connection between these pathways, indicating that further investigation may reveal new functions shared by them, and their cooperation in maintaining ge...Continue Reading

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Citations

Jul 30, 2020·Cancers·Amandine Moretton, Joanna I Loizou
Oct 4, 2020·Nucleic Acids Research·Namrata KumarBennett Van Houten
Nov 12, 2020·International Journal of Molecular Sciences·Ostiane D'AugustinJuan Pablo Radicella
Mar 9, 2021·Cellular and Molecular Life Sciences : CMLS·Leonardo Vinícius Monteiro de Assis, Henrik Oster
Mar 7, 2021·International Journal of Molecular Sciences·Sripriya Raja, Bennett Van Houten
Nov 18, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine TopkaKenneth Offit
Apr 4, 2021·International Journal of Molecular Sciences·Vladimir Shafirovich, Nicholas E Geacintov
May 13, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Yuko IbukiTatsushi Toyooka
Oct 17, 2020·Critical Reviews in Toxicology·Juliana P PaivaMarcelo de Pádula
Jul 3, 2021·International Journal of Molecular Sciences·Yuliya KrasikovaOlga Lavrik
Sep 14, 2021·Photochemistry and Photobiology·Nathalia Quintero-RuizCarlos Frederico Martins Menck

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Methods Mentioned

BETA
electrophoresis
deamination
co-immunoprecipitation
fluorescence recovery after photobleaching
glycosylases
ubiquitination

Software Mentioned

Cytoscape
STRING
CentiScaPe

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