Cooperation between alteration of DNA gyrase genes and over-expression of MexB and MexX confers high-level fluoroquinolone resistance in Pseudomonas aeruginosa strains isolated from a patient who received a liver transplant followed by treatment with fluoroquinolones

Microbiology and Immunology
Toshiyuki NigaM Inoue

Abstract

Clinical isolates of highly fluoroquinolone-resistant Pseudomonas aeruginosa had a mutation in either A or B subunit of DNA gyrase and over-expressed MexB and MexX, the efflux system proteins. Introduction of wild-type gyrase genes of Escherichia coli into the isolates made them as fluoroquinolonesusceptible as the moderately fluoroquinolone-resistant strains that only over-expressed efflux system proteins. These findings demonstrate that high fluoroquinolone-resistance in P. aeruginosa is attributed to cooperation between alteration in DNA gyrase genes and over-expression of efflux systems proteins.

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Citations

Jul 23, 2008·Antimicrobial Agents and Chemotherapy·Mette E SkindersoeMichael Givskov
Aug 2, 2011·Transplantation Reviews·William H Kitchens
Nov 23, 2006·The Journal of Antimicrobial Chemotherapy·Teresa QuinnSéamus Fanning
Feb 10, 2007·The Journal of Antimicrobial Chemotherapy·Narcisa MesarosFrançoise Van Bambeke
Apr 26, 2007·Annals of Medicine·Keith Poole

Related Concepts

MexB protein, Pseudomonas aeruginosa
MexXY protein, Pseudomonas aeruginosa
Outer Membrane Lipoproteins, Bacterial
Bacterial Proteins
Pseudomonas aeruginosa
Pseudomonas Infections
Gene Expression
Transplantation of Liver
Fluoroquinolones
Antibiotic Resistance, Bacterial

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.