Cooperation of B cells and T cells is required for survival of mice infected with vesicular stomatitis virus

International Immunology
A R ThomsenJ P Christensen

Abstract

To define the role of T cells and B cells in resistance to vesicular stomatitis virus (VSV) infection, knockout mice with different specific immune defects on an identical background were infected i.v. and the outcome of infection was compared; in this way a more complete picture of the relative importance of various host defence mechanisms could be obtained. Compared to T and B cell-deficient SCID mice which all succumbed from encephalitis within 5-9 days of infection, T cell-deficient nude mice generally lived longer, but within a period of approximately 1 month after challenge all died. In contrast, B cell-deficient mice were highly susceptible even to low doses of virus and mortality could be prevented by transfer of naive B cells prior to challenge as well as by immune serum given after challenge. Analysis of MHC class I- and class II-deficient mice revealed that CD8+ T cells could exert some antiviral activity, but CD4+ T cells sufficed for survival and were required for optimal resistance. Consistent with this it was found that in nude mice a lethal outcome could be prevented by transfer of CD8-depleted cells from B cell-deficient mice. Thus our results clearly demonstrate that while antibodies are pivotal for survival i...Continue Reading

Citations

Mar 30, 2002·Trends in Immunology·Dominik WodarzAllan Randrup Thomsen
Aug 10, 2004·Nature Immunology·Mike RecherRolf M Zinkernagel
Feb 25, 2006·Nature Reviews. Immunology·Lars HangartnerHans Hengartner
Jan 24, 2012·Nature Reviews. Immunology·Susan L SwainTara M Strutt
May 17, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Josh A NoserYasuhiro Ikeda
Nov 22, 2005·Oncogene·Glen N Barber
Oct 19, 1999·The Journal of Experimental Medicine·A F OchsenbeinR M Zinkernagel
Jan 27, 2005·Viral Immunology·Glen N Barber
Jul 15, 2003·Clinical Microbiology Reviews·David K Henderson
Nov 22, 2005·Infection and Immunity·Eric YagerGary Winslow
Dec 25, 2003·Journal of Virology·Manisha GuptaPierre E Rollin
May 26, 1999·Clinical and Experimental Immunology·C BartholdyA R Thomsen
Nov 21, 2013·The Journal of Surgical Research·Aaron U BlackhamJohn H Stewart
Mar 27, 2007·Cancer Letters·Markus J V Vähä-KoskelaAri E Hinkkanen
Sep 11, 2004·Current Opinion in Microbiology·Mike RecherKarl S Lang
Apr 2, 2016·ILAR Journal·Theresa FallsMarie-Claude Bourgeois-Daigneault
Aug 13, 2013·Molecular Immunology·Vincent Sam Yong TchangJean Pieters
Jun 26, 2013·Virus Research·Eric HastieValery Z Grdzelishvili
May 19, 2000·Journal of Theoretical Biology·R A Arnaout, M A Nowak
Jun 9, 2006·European Journal of Immunology·Tord LabudaNiels Odum
May 29, 2004·The Journal of General Virology·Nanna Ny KristensenJan Pravsgaard Christensen
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia N DetjeUlrich Kalinke
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina BartholdyAllan Randrup Thomsen
Aug 17, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia SpanierUlrich Kalinke
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephan OehenConstantino López-Macías
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard P CiavarraChristina Steel
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter Johannes HolstJan Pravsgaard Christensen

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