Cooperation of endothelin-1 signaling with melanosomes plays a role in developing and/or maintaining human skin hyperpigmentation

Biology Open
Daiki MuraseYoshinori Takema

Abstract

Skin hyperpigmentation is characterized by increased melanin synthesis and deposition that can cause significant psychosocial and psychological distress. Although several cytokine-receptor signaling cascades contribute to the formation of ultraviolet B-induced cutaneous hyperpigmentation, their possible involvement in other types of skin hyperpigmentation has never been clearly addressed. Since our continuous studies using skin specimens from more than 30 subjects with ethnic skin diversity emphasized a consistent augmentation in the expression of endothelin-1 (ET-1) and its receptor (Endothelin B receptor, ET-B) in hyperpigmented lesions, including senile lentigos (SLs), the precise function of ET-1 signaling was investigated in the present study. In line with previous studies, ET-1 significantly induced melanogenesis followed by increases in melanosome transport in melanocytes and in its transfer to keratinocytes while inhibition of ET-B function substantially depressed melanogenic ability in tissue-cultured SLs. Additionally, in agreement with a previous report that the formation of autophagosomes rather than melanosomes is stimulated according to starvation or defective melanosome production, ET-1 was found to remarkably au...Continue Reading

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Citations

Sep 13, 2020·Journal of Cellular and Molecular Medicine·Chaoshuai ZhaoWeimin Shi
Dec 23, 2016·The Journal of Biological Chemistry·Jaroslaw SzczyrbaGunther Wennemuth
Aug 14, 2020·International Journal of Molecular Sciences·Daiki MuraseTamotsu Yoshimori
Oct 20, 2020·Pharmacology & Therapeutics·Xiaoyu TianRutao Cui

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Methods Mentioned

BETA
GTPase
biopsies
PCR
Assay
ELISA
biopsy
protein assay
electrophoresis

Software Mentioned

ImageJ
IntegReview

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