Cooperation of Hoxa5 and Pax1 genes during formation of the pectoral girdle

Developmental Biology
J AubinLucie Jeannotte

Abstract

Hox and Pax transcription factors are master regulators of skeletal and organ morphogenesis. Some skeletal malformations encountered in Hoxa5 mutants are shared by the undulated (un) mice, which bear a point mutation in the Pax1 gene. To investigate whether Hoxa5 and Pax1 act in common pathways during skeletal development, we analyzed Hoxa5;un compound mutants. Our genetic studies show that Hoxa5 and Pax1 cooperate in the vertebral patterning of the cervicothoracic transition region and in acromion morphogenesis. The dynamics of expression of Hoxa5 and Pax1 in the pectoral girdle region suggest that both genes function in a complementary fashion during acromion formation. Whereas Pax1 is required for the recruitment of acromion precursor cells, Hoxa5 may provide regional cues essential for the correct formation of the acromion by ensuring Pax1 expression at the proper time and position during morphogenesis of the pectoral girdle. Hoxa5 also has a distinctive role in specifying the fate of perichondrial and chondrogenic cell lineages in a Sox9-dependent way.

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Citations

Jun 1, 2005·Gene Expression Patterns : GEP·Milan JoksimovicChristopher K Tuggle
Jan 22, 2009·Médecine sciences : M/S·Olivier BoucheratLucie Jeannotte
May 18, 2007·Annual Review of Cell and Developmental Biology·Margaret Buckingham, Frédéric Relaix
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Sep 17, 2015·Evolution; International Journal of Organic Evolution·Karen E SearsRui Diogo
Sep 28, 2006·The American Journal of Pathology·Isabel MandevilleLucie Jeannotte
Mar 7, 2013·Mechanisms of Development·Jessica W ChenJennifer H Mansfield
Jan 28, 2017·American Journal of Physical Anthropology·Michael S Selby, C Owen Lovejoy
Aug 23, 2017·Development·Kim Landry-TruchonLucie Jeannotte
Jun 20, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Dominique MeunierLucie Jeannotte
Apr 12, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elisabeth GarinLucie Jeannotte
Apr 10, 2007·Genesis : the Journal of Genetics and Development·Sébastien TabarièsLucie Jeannotte
Aug 1, 2018·Frontiers in Cell and Developmental Biology·Thomas W P Wood, Tetsuya Nakamura
Jan 12, 2005·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Yoshie Kawashima OhyaShigeru Kuratani
Mar 25, 2016·Journal of Developmental Biology·Lucie JeannotteKim Landry-Truchon

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