Cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic States in Arabidopsis.

The Plant Cell
Tuncay BaubecOrtrun Mittelsten Scheid

Abstract

Epigenetic changes of gene expression can potentially be reversed by developmental programs, genetic manipulation, or pharmacological interference. However, a case of transcriptional gene silencing, originally observed in tetraploid Arabidopsis thaliana plants, created an epiallele resistant to many mutations or inhibitor treatments that activate many other suppressed genes. This raised the question about the molecular basis of this extreme stability. A combination of forward and reverse genetics and drug application provides evidence for an epigenetic double lock that is only alleviated upon the simultaneous removal of both DNA methylation and histone methylation. Therefore, the cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic states and contributes to heritable diversity of gene expression patterns.

References

Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Sep 1, 1995·The Plant Journal : for Cell and Molecular Biology·Y G LiuR F Whittier
May 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M YoshidaT Beppu
Jun 25, 1993·Science·A VongsE J Richards
Feb 11, 1993·Nucleic Acids Research·P Bork, E V Koonin
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·T KakutaniE J Richards
Feb 12, 1998·The Plant Journal : for Cell and Molecular Biology·T MengisteJ Paszkowski
May 13, 1999·Nature Genetics·J A JeddelohE J Richards
Aug 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·O Mittelsten ScheidJ Paszkowski
Sep 22, 2000·Plant Molecular Biology·V L ChandlerJ E Dorweiler
Oct 14, 2000·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·A KovaríkM Bezdek
Feb 22, 2002·Current Opinion in Plant Biology·E Jean Finnegan
Jun 22, 2002·Science·Anne-Valérie GendrelRobert A Martienssen
Aug 27, 2002·Current Biology : CB·Lianna JohnsonSteven Jacobsen
Oct 31, 2002·The Journal of Biological Chemistry·Jan Brzeski, Andrzej Jerzmanowski
Mar 1, 2003·The Plant Journal : for Cell and Molecular Biology·Aline V ProbstOrtrun Mittelsten Scheid
Mar 5, 2003·Trends in Genetics : TIG·Thomas C OsbornRobert A Martienssen
Mar 7, 2003·Current Biology : CB·Masaomi KatoTetsuji Kakutani
Jul 9, 2003·Nature Genetics·Ortrun Mittelsten ScheidJerzy Paszkowski
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad TariqJerzy Paszkowski
Jul 23, 2004·Nature·Zachary LippmanRob Martienssen
Aug 21, 2004·Annals of Botany·Andreas Madlung, Luca Comai
Nov 9, 2004·Current Opinion in Genetics & Development·Suyinn Chong, Emma Whitelaw
Mar 9, 2005·Current Opinion in Plant Biology·Keith L Adams, Jonathan F Wendel
Sep 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Cheng-Ran XuShu-Nong Bai
Mar 21, 2006·Biochemical Society Transactions·W A M Loenen
Mar 21, 2006·Trends in Plant Science·Jörg FuchsIngo Schubert
May 17, 2006·Trends in Ecology & Evolution·Susan Kalisz, Michael D Purugganan

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Citations

Jan 12, 2013·Journal of Experimental Botany·Riccardo AversanoDomenico Carputo
Apr 20, 2012·Plant & Cell Physiology·Chang-Ho EunKazuo Tsugane
Jan 26, 2010·The Plant Cell·Nancy A Eckardt
Oct 27, 2011·PLoS Genetics·Andrea M FoersterOrtrun Mittelsten Scheid
Aug 24, 2010·FEBS Letters·Peter Meyer
Apr 1, 2011·Current Opinion in Plant Biology·Marie Mirouze, Jerzy Paszkowski
Mar 18, 2011·Current Opinion in Plant Biology·Marc De Block, Mieke Van Lijsebettens
Jun 7, 2014·Annals of the New York Academy of Sciences·Gaurav D Moghe, Shin-Han Shiu
Sep 12, 2015·Annual Review of Cell and Developmental Biology·Ryan JankeJasper Rine
Jul 11, 2013·Plant Signaling & Behavior·Huiming ZhangJian-Kang Zhu
Jun 19, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Kateřina KřížováAleš Kovařík
Mar 15, 2015·Current Opinion in Plant Biology·Qingxin Song, Z Jeffrey Chen
Jan 13, 2015·Cellular and Molecular Life Sciences : CMLS·Cécile VrietChristophe Laloi
Aug 18, 2016·Journal of Experimental Botany·Yuan ShenDao-Xiu Zhou
Aug 28, 2013·Genetics·Meru J SadhuJasper Rine
Jun 20, 2019·Frontiers in Plant Science·Daniel KuźnickiJolanta Floryszak-Wieczorek
Jun 14, 2019·Frontiers in Plant Science·Alexandra Ageeva-KieferleChristian Lindermayr
Jan 27, 2021·Current Opinion in Plant Biology·Naseem SamoIva Mozgová
Mar 23, 2020·Molecular Metabolism·Christian LindermayrMartin Groth
Mar 16, 2021·PeerJ·Devendra Ram MalaviyaRuslan Kalendar
May 22, 2021·Journal of Experimental Botany·Athanasios Dalakouras, Dimitrios Vlachostergios

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