PMID: 8612614Mar 1, 1996Paper

Cooperation of tyrosine kinases p72syk and p53/56lyn regulates calcium mobilization in chicken B cell oxidant stress signaling

European Journal of Biochemistry
S QinH Yamamura

Abstract

A chicken B cell line DT40 and its syk-negative or lyn-negative mutants were used to investigate the roles of protein-tyrosine kinases in oxidant stress signaling. The data presented here for wild-type cells demonstrate that hydrogen peroxide stimulates p53/56lyn-dependent tyrosine phosphorylation and activation of p72syk, and induces a rapid and prolonged elevation of intracellular calcium, which consists of calcium release from intracellular stores and influx from the extracellular space. Hydrogen-peroxide-triggered calcium mobilization was impaired in both syk-negative and lyn-negative cells, which was mainly due to the loss of calcium release from intracellular stores. Further studies indicated that inositol trisphosphate production was also abolished in both syk-negative and lyn-negative cells, which is consistent with the loss of calcium release. Taken together, these observations suggest that the defect of p72syk or p53/56lyn was responsible for the abnormality of calcium mobilization in both lyn-negative and syk-negative cells, and that both p72syk and p53/56lyn might regulate calcium mobilization through the phosphatidylinositol pathway in B cell oxidant stress signaling.

References

Sep 1, 1992·Archives of Biochemistry and Biophysics·A RoveriF Ursini
Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Dec 1, 1986·Journal of Cellular Physiology·P A HyslopC G Cochrane
May 1, 1994·The Journal of Experimental Medicine·T KurosakiH Yamamura
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·C CoutureT Mustelin
May 19, 1995·The Journal of Biological Chemistry·A L Sillman, J G Monroe
Nov 1, 1994·Molecular and Cellular Biology·A HataH Hanafusa
Apr 1, 1994·Molecular and Cellular Biology·C E DabrowskiP A Schaffer
Jan 1, 1994·Geburtshilfe und Frauenheilkunde·H SchneiderW Hänggi
Jul 16, 1993·Cell·W KolanusB Seed
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R DattaD W Kufe
Aug 1, 1991·Trends in Cell Biology·R Schreck, P A Baeuerle

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Citations

Feb 28, 2001·Journal of Immunological Methods·P Winding, M W Berchtold
Jun 25, 2002·Molecular Aspects of Medicine·Malcolm J JacksonSiân B Astley
Sep 10, 2003·Hematology/oncology Clinics of North America·Gustavo Rodriguez
Oct 24, 2003·Free Radical Biology & Medicine·Chellappa VasantThirumalachari Ramasami
Mar 4, 2000·Free Radical Biology & Medicine·R G Allen, M Tresini
Apr 17, 1999·Cellular Signalling·H Kamata, H Hirata
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·S QinP B Chock
Jan 30, 2002·Antioxidants & Redox Signaling·W HanH Yamamura
Sep 7, 2002·Antioxidants & Redox Signaling·Andras PerlKatalin Banki
Sep 7, 2002·Antioxidants & Redox Signaling·Suofu Qin, P Boon Chock
Sep 7, 2002·Antioxidants & Redox Signaling·Jinsong HeHirohei Yamamura
Sep 7, 2002·Antioxidants & Redox Signaling·Tomoko TakanoHirohei Yamamura
Sep 7, 2002·Antioxidants & Redox Signaling·Cornelis L Verweij, Sonja I Gringhuis
May 4, 2011·World Journal of Biological Chemistry·Suofu Qin
Dec 16, 1998·The Journal of Physiology·P Krippeit-DrewsG Drews
Oct 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Heide Christine PattersonHarvey F Lodish
Dec 23, 1999·Current Biology : CB·H KubistaS E Moss
Jan 27, 1999·Biochimica Et Biophysica Acta·H KubistaS E Moss
Jul 22, 2010·Cell Calcium·Morten GrupeAndrea Fleig
Aug 17, 2016·Oxidative Medicine and Cellular Longevity·Meriem H Ben-MahdiCatherine Pasquier
Jun 9, 2009·Immunology Letters·Noriaki OkamotoDaisuke Kitamura
Oct 16, 2007·Biochemical and Biophysical Research Communications·Takahiro AdachiTomohiro Kurosaki
Jun 19, 2004·International Reviews of Immunology·Andras PerlKatalin Banki
Sep 12, 2001·The Journal of Biological Chemistry·K L OtipobyE A Clark
May 12, 2018·Molecular Medicine Reports·Yanfei Cui, Shengya Yang
Jul 25, 2000·The Journal of Biological Chemistry·J DingH Yamamura
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Allison L MillerClifford A Lowell
Oct 19, 2001·The Journal of Biological Chemistry·R RodriguezM Katan
Aug 17, 1999·Biochemical and Biophysical Research Communications·S QinH Yamamura
Jan 22, 1998·Biochemical and Biophysical Research Communications·Y SonodaS Watanabe

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