Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development

Development
Daisuke SakaiYoshio Wakamatsu

Abstract

In neural crest formation, transcription factors, such as group E Sox and Snail1/Snail2 (Slug) regulate subsequent epithelial-mesenchymal transition (EMT) and migration. In particular, Sox9 has a strong effect on neural crest formation, EMT and differentiation of crest-derived cartilages in the cranium. It remains unclear, however, how Sox9 functions in these events, and how Sox9 activity is regulated. In this study, our gain-of-function and loss-of-function experiments reveal that Sox9 is essential for BMP signal-mediated induction of Snail2 and subsequent EMT in avian neural crest. We also show that Snail2 activates the Snail2 promoter, although Snail family proteins have been known as a repressor. Consistently, Sox9 directly activates the Snail2 promoter in synergy with, and through a direct binding to, Snail2. Finally, functions of these transcription factors in neural crest cells are enhanced by PKA signaling.

References

Apr 1, 1997·Molecular and Cellular Biology·V LefebvreB de Crombrugghe
Jun 24, 2000·Molecular and Cellular Biology·K HemavathyY T Ip
Jun 29, 2000·Annual Review of Biochemistry·A J Shaywitz, M E Greenberg
Jul 6, 2000·Brain Research. Developmental Brain Research·Y ChengP J Scotting
Jan 11, 2002·Developmental Biology·Sandra VillanuevaRoberto Mayor
Mar 20, 2002·Developmental Biology·Sandrine FaureMalcolm Whitman
May 8, 2002·Nature Reviews. Molecular Cell Biology·M Angela Nieto
May 23, 2002·The Journal of Biological Chemistry·Po ZhaoEric P Hoffman
Dec 24, 2002·Trends in Neurosciences·Jinling WuPeter S Klein
Jul 30, 2003·Developmental Biology·Stella M HonoréRoberto Mayor
Oct 3, 2003·Development·Martin Cheung, James Briscoe
Dec 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yoshio WakamatsuJames A Weston
Dec 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Francisco BastidasRoberto Mayor
Sep 15, 2004·Developmental Cell·Daniel Meulemans, Marianne Bronner-Fraser
Oct 7, 2004·Developmental Biology·Young-Hoon LeeJean-Pierre Saint-Jeannet
Nov 24, 2004·The International Journal of Developmental Biology·Hisato KondohYusuke Kamachi
Feb 5, 2005·Developmental Cell·Martin CheungJames Briscoe
Mar 16, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sonja J McKeownPeter G Farlie
May 21, 2005·The International Journal of Developmental Biology·Chaya Kalcheim, Tal Burstyn-Cohen
Jun 9, 2005·Cells, Tissues, Organs·Daisuke Sakai, Yoshio Wakamatsu
Jun 29, 2005·Development·Alejandro Barrallo-Gimeno, M Angela Nieto
Sep 24, 2005·Development, Growth & Differentiation·Daisuke SakaiYoshio Wakamatsu

❮ Previous
Next ❯

Citations

May 2, 2012·Cellular and Molecular Life Sciences : CMLS·Timothy J Stuhlmiller, Martín I García-Castro
May 18, 2007·Nature Reviews. Cancer·Héctor PeinadoAmparo Cano
Apr 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tadayoshi WatanabeYoshiko Takahashi
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Allison S HarneyThomas J Meade
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jessica A J LiuMartin Cheung
Dec 17, 2009·Tissue Engineering. Part a·Hsing-I HuangShu-Hui Chan
Jun 15, 2011·Carcinogenesis·Jin-Yuan Shih, Pan-Chyr Yang
Apr 18, 2006·Nucleic Acids Research·Sandra PeiróAntonio García de Herreros
Dec 3, 2008·Development, Growth & Differentiation·Yukiko Nakaya, Guojun Sheng
Jan 9, 2009·Development, Growth & Differentiation·Jean-Loup DubandClaire Fournier-Thibault
May 29, 2010·Development, Growth & Differentiation·Yoshiaki TamanoueHarumasa Okamoto
Apr 16, 2011·Development, Growth & Differentiation·Takashi YoshinoYoshiko Takahashi
Feb 5, 2010·BMC Molecular Biology·Elisabetta LambertiniRoberta Piva
May 15, 2009·Development·Brigitte L ArduiniPaul D Henion
Mar 26, 2013·Journal of Cell Science·Sonali SonnylalBenoit de Crombrugghe
Jan 29, 2008·Acta Histochemica Et Cytochemica·Takeshi SuzukiKuniaki Takata
Jan 6, 2007·PloS One·Chi ZhangMichael W Klymkowsky
Nov 19, 2010·PloS One·Carol Lynn CurchoeAlexey V Terskikh
Feb 22, 2014·Nature Reviews. Molecular Cell Biology·Samy LamouilleRik Derynck
May 11, 2010·Journal of Mammary Gland Biology and Neoplasia·Antonio Garcia de HerrerosPierre Savagner
Apr 24, 2014·Gene Expression Patterns : GEP·Sílvia Ferreira de SousaAtsushi Ohazama
Jun 22, 2011·Nature Reviews. Urology·Jones T Nauseef, Michael D Henry
Oct 24, 2012·The Journal of Cell Biology·Chathurani S Jayasena, Marianne E Bronner
Jan 20, 2016·Journal of Clinical Medicine·Mohammed L AbbaHeike Allgayer
Jan 18, 2011·Trends in Molecular Medicine·James PritchettKaren Piper Hanley
Sep 14, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D W MeechanA-S LaMantia
Jul 15, 2015·Biochimica Et Biophysica Acta·Brijesh KumarSharmila A Bapat
Mar 13, 2016·Breast Cancer Research and Treatment·Maria Cristina RangelDavid S Salomon
Jun 17, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Dhimankrishna GhoshQiang Tian
Jan 17, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Shigeru Kuratani, Kinya G Ota
Oct 10, 2006·Development, Growth & Differentiation·Takashi SuzukiYoshio Wakamatsu
Aug 24, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Robert N Kelsh
Jun 7, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gerhard Schlosser
Feb 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jane Khudyakov, Marianne Bronner-Fraser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.