Cooperative binding: a multiple personality

Journal of Mathematical Biology
Johannes W R MartiniMichael Habeck

Abstract

Cooperative binding has been described in many publications and has been related to or defined by several different properties of the binding behavior of the ligand to the target molecule. In addition to the commonly used Hill coefficient, other characteristics such as a sigmoidal shape of the overall titration curve in a linear plot, a change of ligand affinity of the other binding sites when a site of the target molecule becomes occupied, or complex roots of the binding polynomial have been used to define or to quantify cooperative binding. In this work, we analyze how the different properties are related in the most general model for binding curves based on the grand canonical partition function and present several examples which highlight differences between the cooperativity characterizing properties which are discussed. Our results mainly show that among the presented definitions there are not two which fully coincide. Moreover, this work poses the question whether it can make sense to distinguish between positive and negative cooperativity based on the macroscopic binding isotherm only. This article shall emphasize that scientists who investigate cooperative effects in biological systems could help avoiding misunderstand...Continue Reading

References

Apr 12, 2001·Biochemistry·A OnufrievG M Ullmann
Sep 12, 2009·Angewandte Chemie·Christopher A Hunter, Harry L Anderson
Jul 20, 2010·Interdisciplinary Sciences, Computational Life Sciences·Hao Ge, Min Qian
Mar 1, 2012·Journal of Mathematical Biology·Johannes W R Martini, G Matthias Ullmann
Jul 12, 2013·PLoS Computational Biology·Melanie I Stefan, Nicolas Le Novère
Jul 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Katarzyna KaczanowskaPalmer Taylor
Mar 10, 2015·The Journal of Chemical Physics·Johannes W R Martini, Michael Habeck

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Citations

Apr 3, 2016·Journal of Mathematical Biology·Hagai Abeliovich
Oct 28, 2016·Journal of Mathematical Biology·Melanie I Stefan
Jun 22, 2018·Physical Chemistry Chemical Physics : PCCP·Chunying RongShubin Liu
May 28, 2016·Bulletin of Mathematical Biology·Johannes W R MartiniStefan Schütz
Oct 5, 2018·Journal of Mathematical Biology·Yue RenJacinta Torres
Sep 25, 2020·Journal of Mathematical Biology·Nidhi KaihnsaJohannes W R Martini
Mar 28, 2019·The Journal of Physical Chemistry Letters·Chunying RongShubin Liu

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