Cooperative binding of primycin and gramicidin on erythrocyte membranes. A cation transport study.

Membrane Biochemistry
I P Suga'rA A Lev

Abstract

In this paper the authors present a comparative study of the actions of the antibiotics primycin and gramicidin on the erythrocyte membrane permeability. It has been found that both antibiotics have a nonlinear effect on the membrane permeability. Above a threshold antibiotic concentration, which is characteristic of the type of the antibiotic, the cation permeability of the erythrocyte membranes increases sharply. In the range of nonlinearity the transport-kinetic curves level off before achieving the equilibrium radioactive ion distribution between the extra- and intracellular spaces. A stochastic model of the cooperative and aspecific incorporation of antibiotic molecules into the membrane explains the experimental findings. The authors conclude that membrane permeability increases at the places where two or more antibiotic molecules form aggregates in the membrane.

References

Feb 1, 1979·The Journal of Antibiotics·L MészárosI Horváth
May 1, 1979·Archives of Microbiology·I HorváthK G Büki
Oct 29, 1974·Biochimica Et Biophysica Acta·E Bamberg, P Läuger
Dec 17, 1974·Biochemistry·W R VeatchE R Blout
Aug 9, 1972·Biochimica Et Biophysica Acta·V B Myers, D A Haydon
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D W UrryD F Mayers
Sep 23, 1970·Journal of the American Chemical Society·J AberhartI Szilágyi

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