Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation.

The European Journal of Neuroscience
Takako Ohno-ShosakuMasanobu Kano

Abstract

Endocannabinoids are retrograde messengers that are released from central neurons by depolarization-induced elevation of intracellular Ca2+ concentration [Ca2+]I or by activation of a group I metabotropic glutamate receptor (mGluR). We studied the interaction between these two pathways for endocannabinoid production in rat hippocampal neurons. We made a paired whole-cell recording from cultured hippocampal neurons with inhibitory synaptic connections. Activation of group I mGluRs, mainly mGluR5, by the specific agonist (RS)-3,5-dihydroxyphenylglycine (DHPG), suppressed inhibitory postsynaptic currents (IPSCs) in about half of the neuron pairs. A cannabinoid agonist, WIN55,212-2, suppressed IPSCs in all DHPG-sensitive pairs but not in most of DHPG-insensitive pairs. The effects of both DHPG and WIN55,212-2 were abolished by the cannabinoid antagonists, AM281 and SR141716A, indicating that activation of group I mGluR releases endocannabinoids and suppress inhibitory neurotransmitter release through activation of presynaptic cannabinoid receptors. Depolarization of the postsynaptic neurons caused a transient suppression of IPSCs, a phemomenon termed depolarization-induced suppression of inhibition (DSI) that was also abolished by ...Continue Reading

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Citations

Jul 19, 2006·Cell and Tissue Research·Francesco Ferraguti, Ryuichi Shigemoto
Nov 19, 2004·Der Schmerz·R RukwiedC Konrad
Sep 29, 2007·Journal of Molecular Neuroscience : MN·David M Lovinger
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Jul 7, 2007·The Journal of Physiology·Takako Ohno-ShosakuMasanobu Kano
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