Abstract
The Department of Veterans Affairs, through its Cooperative Studies Program, has a long history of conducting large-scale, multihospital biomedical clinical trials. The agency's Health Services Research and Development Service, although newer, has a distinguished record of mainly single-site research into the organization, delivery, and financing of health services. In 1990, a joint program was initiated to conduct multicenter studies in health services research. This article describes the studies developed in the new program and the research design issues encountered in planning them. Identification of the patient population, specification and measurement of the intervention, and description of the control group, as well as attention to the unit of randomization and analysis, outcome variables and choice of effect size, data quality, and ethical considerations are among the important issues related to the design of these studies and future studies in health services.
References
Dec 8, 1983·The New England Journal of Medicine·R H BrookJ P Newhouse
Aug 1, 1983·Medical Care·M S MarquisJ E Ware
Dec 1, 1981·Controlled Clinical Trials·B A KatheP Fehm
Dec 1, 1980·Controlled Clinical Trials·K E James
Dec 1, 1980·Controlled Clinical Trials·W G Henderson
Oct 1, 1995·Medical Care·M J McCarthyD Miller
Oct 1, 1995·Medical Care·W G HendersonK E Hammermeister
Aug 1, 1995·Journal of Clinical Epidemiology·E OddoneD Simel
Feb 1, 1995·Journal of the American College of Cardiology·J A SpertusS D Fihn
Dec 1, 1994·The Annals of Thoracic Surgery·F L GroverK E Hammermeister
Apr 15, 1993·Annals of Internal Medicine·G H GuyattD L Patrick
Jun 2, 1993·JAMA : the Journal of the American Medical Association·D Blumenthal
Feb 1, 1996·Journal of Clinical Epidemiology·M WeinbergerP B Landsman
May 30, 1996·The New England Journal of Medicine·M WeinbergerW G Henderson
Sep 19, 1997·The New England Journal of Medicine·R RosenheckD Charney
Citations
Aug 28, 2001·Statistics in Medicine·S S Ellenberg
Apr 29, 1998·Controlled Clinical Trials·L M Manheim
Apr 27, 1999·Medical Care·D HynesW Henderson
Mar 5, 2004·American Journal of Public Health·Allan Donner, Neil Klar
Jun 19, 2001·Medical Care·M WeinbergerJ R Feussner
Jun 30, 2019·Journal of the American Medical Directors Association·Allison M GustavsonUNKNOWN PACRATS Investigators