Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.

Oncogene
Nikolai KhodarevDonald Kufe

Abstract

Signal transducer and activator of transcription 1 (STAT1) is activated in the inflammatory response to interferons. The MUC1 oncoprotein is overexpressed in human breast cancers. Analysis of genes differentially expressed in MUC1-transformed cells has identified a network linking MUC1 and STAT1 that is associated with cellular growth and inflammation. The results further show that the MUC1-C subunit associates with STAT1 in cells and the MUC1-C cytoplasmic domain binds directly to the STAT1 DNA-binding domain. The interaction between MUC1-C and STAT1 is inducible by IFNgamma in non-malignant epithelial cells and constitutive in breast cancer cells. Moreover, the MUC1-STAT1 interaction contributes to the activation of STAT1 target genes, including MUC1 itself. Analysis of two independent databases showed that MUC1 and STAT1 are coexpressed in about 15% of primary human breast tumors. Coexpression of MUC1 and the STAT1 pathway was found to be significantly associated with decreased recurrence-free and overall survival. These findings indicate that (i) MUC1 and STAT1 function in an auto-inductive loop, and (ii) activation of both MUC1 and the STAT1 pathway in breast tumors confers a poor prognosis for patients.

References

Oct 6, 1995·The Journal of Biological Chemistry·G A DeblandreM G Wathelet
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·S D DerR H Silverman
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Mar 6, 2002·The Journal of Biological Chemistry·Jian RenDonald Kufe
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·David E Levy, J E Darnell
Feb 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nikolai N KhodarevRalph R Weichselbaum
Feb 18, 2004·Nature Reviews. Cancer·Hua Yu, Richard Jove
Dec 22, 2005·Nature Structural & Molecular Biology·Bertil MacaoTorleif Härd
Jan 24, 2006·Molecular Cell·Xiaolong WeiDonald Kufe
Feb 17, 2006·Genes & Development·Oliver H KrämerThorsten Heinzel
Apr 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sherene LoiChristos Sotiriou
May 15, 2007·The Journal of Biological Chemistry·Yumei LengDonald Kufe
May 16, 2007·The Journal of Biological Chemistry·Christian SchindlerThomas Decker
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maïa ChanrionJean-Marie Darbon
Nov 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ralph R WeichselbaumAndy J Minn
Jan 28, 2009·Genes & Development·Oliver H KrämerThorsten Heinzel
Mar 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sean P PitrodaRalph R Weichselbaum

❮ Previous
Next ❯

Citations

Feb 25, 2011·Molecular Pharmacology·Yongchun ZhouDonald Kufe
Feb 18, 2011·Science Signaling·Rehan AhmadDonald Kufe
May 18, 2011·Molecular and Cellular Biology·Filipa AntunesUwe Vinkemeier
Mar 23, 2011·Molecular Cancer Therapeutics·Deepak RainaDonald Kufe
Jan 24, 2012·Breast Cancer Research : BCR·Szeman Ruby ChanRobert D Schreiber
Apr 15, 2014·PloS One·Rui HuangSimon P Langdon
Jan 26, 2011·European Journal of Histochemistry : EJH·E LacunzaM V Croce
Dec 19, 2014·BMC Medical Genomics·Lars OlsenVladimir Brusic
Jul 31, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Abdelfattah M AttallahAhmed M El-Waseef
Dec 1, 2010·Medical Oncology·Dongrong SituTiehua Rong
Sep 25, 2012·Expert Opinion on Biological Therapy·Takashi Kimura, Olivera J Finn
Dec 4, 2015·Cytokine·Katrin MeisslBirgit Strobl
Feb 1, 2011·Biochimica Et Biophysica Acta·Partha MukhopadhyaySurinder K Batra
Mar 31, 2011·Biochimica Et Biophysica Acta·Cristina Isabel Santos, Ana P Costa-Pereira
Jun 5, 2015·British Journal of Cancer·S C WightmanN N Khodarev
Jun 28, 2014·Cellular Signalling·Gaoyong LiaoYong Zhao
Apr 1, 2012·JAK-STAT·Lidia AvalleValeria Poli
Jan 11, 2013·Cell Adhesion & Migration·Teresa M Horm, Joyce A Schroeder
Apr 2, 2013·Molecular and Cellular Endocrinology·S Haricharan, Y Li
Apr 24, 2013·American Journal of Clinical Oncology·Krishna PillaiDavid L Morris
Aug 10, 2016·Cytokine & Growth Factor Reviews·M Alper Kursunel, Gunes Esendagli
Aug 13, 2015·PloS One·Deepak RainaDonald Kufe
May 12, 2018·Journal for Immunotherapy of Cancer·Pradip BajgainJuan F Vera
May 7, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adriana ForeroSaumendra N Sarkar
Jul 2, 2020·OncoTargets and Therapy·Shuya LiuJingbo Wu
Nov 7, 2017·Experimental and Therapeutic Medicine·Tao XuYing Xin
Jun 27, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Xin ZhouXiaodong Cai
Aug 23, 2018·Leukemia·Nicole PrutschOlaf Merkel
Oct 1, 2014·Cancer Research·Budiman KharmaIkuo Konishi

❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts
ChIP
PCR
transfection
xenograft

Software Mentioned

Ingenuity Pathway Analysis ( IPA )
Ingenuity Pathway Analysis
Significance Analysis of Microarrays ( SAM )
JMP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.