PMID: 6987672Feb 1, 1980Paper

Coordinate modulation of D-glucose transport activity and bilayer fluidity in plasma membranes derived from control and insulin-treated adipocytes

Proceedings of the National Academy of Sciences of the United States of America
P F PilchM P Czech

Abstract

The cis-monoenoic fatty acids vaccenate and oleate stimulate D-glucose transport when partitioned into isolated plasma membranes from rat adipocytes. The magnitude of hexose transport stimulation due to these agents is equal to that observed in plasma membranes derived from insulin-treated adipocytes. Addition of cis-unsaturated fatty acids to plasma membranes derived from insulin-treated cells results in no further stimulation of glucose transport over that due to the hormone alone. In contrast, treatment of membranes exhibiting insulin-activated D-glucose transport activity with saturated fatty acids reduces transport activity to control levels. No effect of the saturated fatty acids was observed on D-glucose transport in control membranes. Because cis-unsaturated fatty acids fluidize plasma membranes under the conditions used in these experiments, these data demonstrate a positive correlation between membrane fluidity and adipocyte D-glucose transport system activity. In addition, the results suggest that enhanced bilayer fluidity or increased affinity of the glucose transporter for fluid microenvironments of the membrane may play a key role in transport regulation by insulin.

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Citations

Nov 1, 1996·Cancer Causes & Control : CCC·R Kaaks
Apr 22, 1988·Biochimica Et Biophysica Acta·B López-CorcueraC Aragón
Feb 1, 1985·Prostaglandins·R W Walenga, W Bergstrom
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·M L MichaelisT Tehan
Sep 14, 1984·Biochimica Et Biophysica Acta·Y Shechter, Y I Henis
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Dec 30, 1981·Biochimica Et Biophysica Acta·J R WilliamsonJ B Hoek
Dec 6, 1997·European Journal of Pharmacology·S MullerP Drouin
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·O FontaineH Rasmussen
Sep 1, 1991·The British Journal of Nutrition·P F MohanM P Cleary
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Feb 1, 1991·Clinical Endocrinology·R Taylor
Apr 1, 1990·The Journal of Clinical Investigation·J B MeddingsS Thiesen
Mar 22, 2012·Endocrinology·Kirk M HabeggerJeffrey S Elmendorf
Sep 1, 1988·Molecular and Cellular Endocrinology·W C Gorospe, P M Conn
Aug 1, 1985·Molecular and Cellular Endocrinology·R Horuk, J M Olefsky
Jan 1, 1984·Progress in Biophysics and Molecular Biology·G Benga, R P Holmes
Mar 21, 1983·Biochimica Et Biophysica Acta·R D Moore
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Apr 15, 2014·The Journal of Nutritional Biochemistry·Nolan J HoffmanJeffrey S Elmendorf
Jun 29, 2012·Journal of Cellular Physiology·Saori Morino-KogaHirofumi Kai
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Nov 1, 1983·Metabolism: Clinical and Experimental·G R GourleyW A Olsen
Oct 1, 1986·Biochemical Medicine and Metabolic Biology·G S SidhuR Bhatnagar

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