PMID: 9553866Apr 29, 1998Paper

Coordinate production of PGE2 and IL-1 beta in the gingival crevicular fluid of adults with periodontitis: its relationship to alveolar bone loss and disruption by twice daily treatment with ketorolac tromethamine oral rinse

Journal of Periodontal Research
P F CavanaughM K Jeffcoat

Abstract

The inflammatory mediators prostaglandin E2 (PGE2) and interleukin-1 beta (IL-1 beta) play critical roles in the inflammatory process leading to alveolar bone and connective tissue loss in periodontal disease. Data from a previously published 6-month clinical study demonstrated that twice daily use of 0.1% ketorolac tromethamine oral rinse prevented alveolar bone loss in adults with periodontitis. We further analyzed data from this study to examine the relationship between PGE2. IL-1 beta and bone loss. Patient mean PGE2 and IL-1 beta levels in gingival crevicular fluid (M-GCF) measured throughout the course of the study were directly compared to the maximum amount of alveolar bone height loss observed at a single study site in each patient. The maximum amount of bone loss measured was chosen for the analysis since the pattern of bone loss was clearly episodic in nature. A statistically significant correlation (r = 0.73, p = 0.001) exists between M-GCF PGE2 concentration and the maximum amount of bone height lost at individual patient study sites. The correlation between M-GCF IL-1 beta concentration and maximum bone height lost is also statistically significant (r = 0.66, p = 0.005). Over the 6-month duration of the study, bot...Continue Reading

References

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Citations

Mar 27, 2003·Periodontology 2000·Catherine M E ChampagneSteven Offenbacher
Jun 12, 2004·Journal of Clinical Periodontology·Renate DeinzerArmin Herforth
Jan 12, 2007·Periodontology 2000·Keith L KirkwoodWilliam V Giannobile
Jul 27, 2007·Journal of Dental Research·R R Fitzgerald, J D Walters
Mar 1, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna KatsTülay Yucel-Lindberg
Jan 12, 2008·European Journal of Oral Sciences·Angela Bergmann, Renate Deinzer
Sep 1, 2005·Journal of Clinical Periodontology·Giovanni E Salvi, Niklaus P Lang
Sep 30, 2017·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Mohammad D Al AmriAbdulaziz S Al-Rasheed
Jan 14, 2000·Journal of Periodontal Research·R B JohnsonM A Tucci
Jun 20, 2007·Oral Diseases·D N Della RicciaM G Cifone
Mar 13, 2003·Journal of Clinical Periodontology·Bernd WaschulRenate Deinzer
Aug 2, 2003·The Journal of the American Dental Association·Fan ZhangAndrew J Dannenberg

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