Coordinate regulation of canine glomeruli and adrenal angiotensin receptors by dietary sodium manipulation

Kidney International
W ZhengKathryn Sandberg

Abstract

This study evaluated the effects of dietary sodium manipulation in dogs on the regulation of canine angiotensin receptors (cAT1 and cAT2) in the kidney and adrenal. Isolated glomeruli and membranes from renal medulla and the adrenal gland were used in radioligand binding assays from two groups of dogs: dogs maintained on low-sodium diet for two weeks followed by a high-sodium diet for two weeks (H), and dogs were maintained on the reverse schedule (L). Analysis of the binding data showed that dietary sodium manipulation had no significant effects on cAT1 and cAT2 receptor binding affinities in glomeruli, renal medulla, and adrenal tissues. In contrast, dietary sodium loading induced a marked increase in cAT1 receptor expression in both the glomeruli and adrenal compared with receptor expression in salt-restricted animals [H/L ratio: glomeruli (1.5), renal medulla (1.1), adrenal (1.6)] that inversely correlated with the activity of the plasma renin angiotensin system. Conversely, adrenal cAT2 receptor expression was regulated in an inverse manner in the H and L animal groups [H/L ratio: 0.7]. This study demonstrates that renal glomerular and adrenal AT1 receptors in the dog are coordinately down-regulated by dietary sodium restr...Continue Reading

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Citations

Sep 1, 2004·Hypertension·Carmen Hinojosa-LabordeKathryn Sandberg
Jul 9, 2004·Hypertension·Katarzyna StolarzUNKNOWN European Project On Genes in Hypertension (EPOGH) Investigators
Aug 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sunghou LeeChristine Maric
Feb 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Wei ZhengKathryn Sandberg
Dec 18, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kai ChenJames C Rose
Apr 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hong JiKathryn Sandberg
May 16, 2017·Current Hypertension Reports·Branko BraamShereen M Hamza

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