Coordinate regulation of the expression of axonal proteins by the axonal microenvironment

Developmental Biology
P SondereggerP G Nelson

Abstract

The axonal functions that act in the formation of the neuronal network have been shown to occur in close interdependence with the tissue that surrounds the growing axons. However, little is known about the molecular building blocks underlying axonal functions, although more than 400 axonal proteins have been identified. In view of the existence of such a large number of axonal proteins, we have initiated a project to determine the molecules involved in the implementation of particular axonal functions by a selective approach. On the assumption that plasticity in the expression of axonal functions in response to specific features of the local axonal environment may be based on changes in the expression of particular axonal proteins, the axonal proteins of dorsal root ganglion (DRG) neurons were screened for those whose expression responds to environmental influences. DRG neurons were grown in a compartmental cell system that offers separate access to neuronal somas and to their axons and the axons were locally exposed to different populations of cells from the peripheral or central nervous system. The axonal proteins were metabolically labeled and subjected to two-dimensional gel electrophoresis. Computerized quantitation of the...Continue Reading

References

Jan 1, 1978·Annual Review of Neuroscience·P H Patterson
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T Lorenz, M Willard
Jan 1, 1979·Annual Review of Biophysics and Bioengineering·D L Wilson, G C Stone
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R B Campenot
Jan 1, 1979·Methods in Enzymology·R B Campenot
May 1, 1975·Developmental Biology·P C Letourneau
Nov 1, 1981·Journal of Neurochemistry·G W Perry, D L Wilson
Mar 1, 1983·The Journal of Cell Biology·P LiesiA Vaheri
Sep 23, 1983·Science·P SondereggerP G Nelson
Nov 3, 1983·Nature·C BarnstableM Robertson
Jan 1, 1984·The Journal of Cell Biology·P SondereggerP G Nelson
Jun 1, 1983·Journal of the American Geriatrics Society·E Shapiro
Jun 23, 1983·Nature·P Newmark
Jan 1, 1982·Journal of Neuroscience Research·A Baron-Van EvercoorenM E Dubois-Dalcq
Oct 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·R W SPERRY

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