PMID: 6109007Jan 1, 1981Paper

Coordinate suppression of liver acetyl-CoA carboxylase and fatty acid synthetase by polyunsaturated fat

The Journal of Nutrition
M J ToussantS D Clarke

Abstract

Polyunsaturated fats (PUFA) suppressed hepatic fatty acid synthesis and the activities of lipogenic enzymes more effectively than did saturated fats. The activity of glycolytic enzymes--glucokinase, phosphofructokinase and pyruvate kinase--were not affected by PUFA. The absolute rate of liver fatty acid synthesis after meal ingestion was very similar to the maximal activities of acetyl-CoA carboxylase and fatty acid synthetase. When PUFA was supplemented to a fat-free diet, the activities of carboxylase and synthetase decreased similarly over 3 days. During the 3 days, the concentration of liver malonyl-CoA (after meal ingestion) did not significantly differ between the fat-free and PUFA dietary treatments. Apparently PUFA feeding caused a coordinate decrease in the utilization and production of malonyl-CoA which resulted in no net change in malonyl-CoA pool size. Thus the mechanism by which PUFA suppresses fatty acid synthesis appears to be by coordinately and specifically reducing the amount of carboxylase and fatty acid synthetase.

Citations

Jun 1, 1994·Zeitschrift für Ernährungswissenschaft·K Eder, M Kirchgessner
Mar 1, 1996·Lipids·M T ClandininC J Field
Jan 22, 2002·Journal of Physiology and Biochemistry·V M RodríguezM P Portillo
Dec 1, 1992·The Proceedings of the Nutrition Society·D PerdereauJ Girard
Oct 26, 1999·Endocrine Reviews·B Desvergne, W Wahli
May 1, 2013·Critical Reviews in Food Science and Nutrition·Anthony Fardet, Jean-Michel Chardigny
Jun 1, 1983·The Proceedings of the Nutrition Society·J Pearce
Jun 1, 2014·Applied Microbiology and Biotechnology·Xu ZhaoWei Nie
Sep 2, 1999·Advances in Enzyme Regulation·M R Munday, C J Hemingway
Sep 1, 1996·Progress in Lipid Research·D B JumpM Badin
Feb 16, 1996·Biochimica Et Biophysica Acta·S K Cheema, M T Clandinin
Jan 1, 1993·Progress in Lipid Research·S D Clarke, D B Jump
Apr 1, 1986·Archives of Biochemistry and Biophysics·L M Salati, S D Clarke
Dec 21, 2004·Biochemical and Biophysical Research Communications·Gabriela SuchankovaThomas W Gettys
Oct 1, 1982·Archives of Biochemistry and Biophysics·B A Clarke, S D Clarke
Jun 14, 2005·Biochimica Et Biophysica Acta·Lise MadsenKarsten Kristiansen
May 1, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A Caputi JambrenghiG V Gnoni
Oct 31, 1983·Biochemical and Biophysical Research Communications·S D Clarke

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