PMID: 5916943Oct 28, 1966

Coordinate synthesis of heme and apoenzyme in the formation of tryptophan pyrrolase



Reciprocal control mechanisms between hemoprotein and 8-aminolevulinic acid synthetase take part in coordinate synthesis of the heme and apoenzyme moieties of tryptophan pyrrolase. Stimulation of heme biosynthesis increases tryptophan pyrrolase, whereas enhancement of heme binding by apotryptophan pyrrolase secondarily increases the formation of delta-aminolevulinic acid synthetase, the rate-limiting enzyme in heme formation. Tryptophan-mediated induction of delta-aminolevulinic acid synthetase suggests that heme participates in repression of that enzyme


Dec 1, 1969·Comparative Biochemistry and Physiology·S T BowenT A Grigliatti
Sep 15, 1977·Life Sciences·A A Badawy
Mar 1, 1971·Biochimica Et Biophysica Acta·J A Cutting, H M Schulman
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Mar 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A LorenzenS W Kennedy
Oct 29, 1970·The New England Journal of Medicine·L Kaufman, H S MARVER
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M A Correia, U A Meyer
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Apr 25, 2000·Archives of Biochemistry and Biophysics·S Ren, M A Correia
Nov 20, 1969·Annals of the New York Academy of Sciences·J LascellesB Rittenberg
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Jan 1, 1971·CRC Critical Reviews in Clinical Laboratory Sciences·J PindyckR D Levere

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Enzyme Repression
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