Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons.

David L RoussoBennett G Novitch


The formation of locomotor circuits depends on the spatially organized generation of motor columns that innervate distinct muscle and autonomic nervous system targets along the body axis. Within each spinal segment, multiple motor neuron classes arise from a common progenitor population; however, the mechanisms underlying their diversification remain poorly understood. Here, we show that the Forkhead domain transcription factor Foxp1 plays a critical role in defining the columnar identity of motor neurons at each axial position. Using genetic manipulations, we demonstrate that Foxp1 establishes the pattern of LIM-HD protein expression and accordingly organizes motor axon projections, their connectivity with peripheral targets, and the establishment of motor pools. These functions of Foxp1 act in accordance with the rostrocaudal pattern provided by Hox proteins along the length of the spinal cord, suggesting a model by which motor neuron diversity is achieved through the coordinated actions of Foxp1 and Hox proteins.


Nov 1, 1978·The Journal of Physiology·L Landmesser
Jun 8, 1991·The Journal of Comparative Neurology·A D LindsayJ L Feldman
Nov 1, 1991·Journal of Neurobiology·J A Markham, J E Vaughn
Feb 22, 1987·The Journal of Comparative Neurology·A D Miller
Sep 20, 1981·The Journal of Comparative Neurology·H G Goshgarian, J A Rafols
Mar 11, 1999·Current Opinion in Neurobiology·C Goridis, J F Brunet
Mar 20, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L T Landmesser
Feb 23, 2002·Science·Robert J McEvillyMichael G Rosenfeld
Jun 8, 2002·Annual Review of Neuroscience·Ryuichi Shirasaki, Samuel L Pfaff
Jun 21, 2002·Developmental Biology·J EberhartC E Krull
Aug 15, 2002·Cell·Hynek WichterleThomas M Jessell
Jul 19, 2003·Science·Deneen M Wellik, Mario R Capecchi
Aug 15, 2003·Journal of Neurobiology·Amy W Lin, Ellen M Carpenter
Jan 1, 1964·Progress in Brain Research·G J ROMANES
Oct 31, 2003·Nature·Jeremy S DasenThomas M Jessell
Aug 12, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Veeral ShahCynthia Lance-Jones
May 5, 2005·The European Journal of Neuroscience·Samia CohenFanny Mann
Jan 24, 2006·Nature Reviews. Neuroscience·Giuseppe LupoKatharine E Lewis
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yoh-suke MukouyamaDavid J Anderson
Mar 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Prabakaran SoundararajanVictor F Rafuse

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