Coordinated interaction of Down syndrome cell adhesion molecule and deleted in colorectal cancer with dynamic TUBB3 mediates Netrin-1-induced axon branching

Neuroscience
Huai HuangGuofa Liu

Abstract

Modulation of actin and microtubule (MT) dynamics in neurons is implicated in guidance cue-dependent axon outgrowth, branching and pathfinding. Although the role of MTs in axon guidance has been well known, how extracellular guidance signals engage MT behavior in axon branching remains unclear. Previously, we have shown that TUBB3, the most dynamic β-tubulin isoform in neurons, directly binds to deleted in colorectal cancer (DCC) to regulate MT dynamics in Netrin-1-mediated axon guidance. Here, we report that TUBB3 directly interacted with another Netrin-1 receptor Down syndrome cell adhesion molecule (DSCAM) and Netrin-1 increased this interaction in primary neurons. MT dynamics were required for Netrin-1-promoted association of DSCAM with TUBB3. Knockdown of either DSCAM or DCC or addition of a function blocking anti-DCC antibody mutually blocked Netrin-1-induced interactions, suggesting that DSCAM interdependently coordinated with DCC in Netrin-1-induced binding to TUBB3. Both DSCAM and DCC were partially colocalized with TUBB3 in the axon branch and the axon branching point of primary neurons and Netrin-1 increased these colocalizations. Netrin-1 induced the interaction of endogenous DSCAM with polymerized TUBB3 in primary ...Continue Reading

References

Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·D D O'LearyT Terashima
Oct 18, 1996·Cell·K Keino-MasuM Tessier-Lavigne
Jan 1, 1996·Cell Motility and the Cytoskeleton·A VandecandelaereP M Bayley
Apr 24, 1997·Nature·E D LeonardoM Tessier-Lavigne
Aug 10, 2000·Journal of Neurobiology·G Gallo, P C Letourneau
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jenn-Yah YuDavid L Turner
Dec 20, 2003·Nature Reviews. Neuroscience·Kun-Liang Guan, Yi Rao
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erik W DentKatherine Kalil
Jun 10, 2004·Current Biology : CB·José A Del RíoEduardo Soriano
Jul 10, 2004·Current Biology : CB·Daniel M SuterPaul Forscher
Oct 21, 2004·Nature Neuroscience·Xiu-Rong RenWen-Cheng Xiong
Oct 21, 2004·Nature Neuroscience·Weiquan LiKun-Liang Guan
Nov 24, 2004·The Journal of Cell Biology·Mayya MerianeNathalie Lamarche-Vane
Feb 22, 2005·Current Opinion in Neurobiology·David R Kornack, Roman J Giger
Jul 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fangjun Tang, Katherine Kalil
Oct 13, 2006·Annual Review of Cell and Developmental Biology·Barry J Dickson, Giorgio F Gilestro
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guofa LiuYi Rao
May 8, 2007·Neuron·Michael E HughesDietmar Schmucker
May 8, 2007·Cell·Benjamin J MatthewsWesley B Grueber
Jul 25, 2007·Journal of Cell Science·Mikhail PavelievMart Saarma
Nov 21, 2007·Nature Reviews. Neuroscience·Dietmar Schmucker
Oct 25, 2008·Development·Gracie L AndrewsThomas Kidd
Oct 28, 2008·Trends in Cell Biology·Christopher C Quinn, William G Wadsworth
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jiaping GuJames Q Zheng
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Guofa LiuJane Y Wu
Apr 18, 2009·Nature Reviews. Molecular Cell Biology·Laura Anne Lowery, David Van Vactor
Sep 11, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colleen ManittSusana Cohen-Cory
Nov 26, 2010·Cold Spring Harbor Perspectives in Biology·Erik W DentFrank B Gertler
Dec 3, 2010·Cold Spring Harbor Perspectives in Biology·Alex L Kolodkin, Marc Tessier-Lavigne
May 12, 2011·Development·Karen Lai Wing SunTimothy E Kennedy
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giasuddin AhmedHideaki Tanaka

❮ Previous
Next ❯

Citations

Nov 1, 2015·Developmental Neurobiology·Shruti Jain, Kristy Welshhans
Oct 30, 2016·European Journal of Cell Biology·Irene YlivinkkaMarko Hyytiäinen
May 24, 2020·International Journal of Molecular Sciences·Sung Wook Kim, Kyong-Tai Kim
May 3, 2018·Cerebral Cortex·Olivier D LaflammeFrédéric Bretzner
Aug 16, 2018·Frontiers in Cellular Neuroscience·Nicholas P Boyer, Stephanie L Gupton
Jan 9, 2021·Journal of Child Neurology·Andreea NissenkornLubov Blumkin
Aug 8, 2021·International Journal of Molecular Sciences·Miguel E Domínguez-Romero, Paula G Slater
Aug 28, 2021·International Journal of Molecular Sciences·Maxime LemieuxFrédéric Bretzner
Jun 4, 2021·Annual Review of Vision Science·Mary C Whitman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.