Coordinated multivesicular release at a mammalian ribbon synapse

Nature Neuroscience
Joshua H SingerJ S Diamond

Abstract

Traditional models of synaptic transmission hold that release sites within an active zone operate independently. Although the release of multiple vesicles (multivesicular release; MVR) from single active zones occurs at some central synapses, MVR is not thought to require coordination among release sites. Ribbon synapses seem to be optimized to release many vesicles over an extended period, but the dynamics of MVR at ribbon synapses is unknown. We examined MVR at a ribbon synapse in a retinal slice preparation using paired recordings from presynaptic rod bipolar and postsynaptic AII amacrine cells. When evoked release was highly desynchronized, discrete postsynaptic events were larger than quantal miniature excitatory postsynaptic currents (mEPSCs) but had the same time course. The amplitude of these multiquantal mEPSCs, which seem to arise from the essentially simultaneous release of multiple vesicles, was reduced by lowering release probability. The release synchrony reflected in these multivesicular events suggests that release within an active zone is coordinated during MVR.

References

Nov 8, 1992·The Journal of Comparative Neurology·E StrettoiR F Dacheux
Aug 8, 1991·The Journal of Comparative Neurology·H M Young, D I Vaney
Oct 1, 1991·Trends in Neurosciences·H Korn, D S Faber
Aug 8, 1991·The Journal of Comparative Neurology·D I VaneyH M Young
Mar 1, 1990·The Journal of General Physiology·G Alvarez de Toledo, J M Fernandez
May 15, 1990·The Journal of Comparative Neurology·E StrettoiE Raviola
May 1, 1972·The Journal of Physiology·B Sakitt
May 1, 1982·Journal of Neurophysiology·R Nelson
Apr 1, 1995·Neuron·C F Stevens, Y Wang
Oct 6, 1994·Nature·R HeidelbergerG Matthews
Jun 22, 1993·The Journal of Comparative Neurology·M H ChunH Wässle
Jun 10, 1993·Nature·G Alvarez de ToledoJ M Fernández
Sep 28, 1998·The European Journal of Neuroscience·P KoulenJ H Brandstätter
Jul 31, 1999·The Journal of Biological Chemistry·N J HansenJ M Edwardson
Apr 12, 2000·Journal of Neurophysiology·T Euler, R H Masland
Oct 31, 2001·Neuron·J I Wadiche, C E Jahr
Jun 11, 2002·Nature Neuroscience·Thomas G OertnerKarel Svoboda
Jul 13, 2002·The Journal of Comparative Neurology·Wei LiStephen C Massey
Feb 11, 2003·Neuron·T D Parsons, P Sterling
Apr 28, 1954·The Journal of Physiology·D C HARDWICK
Dec 23, 2003·Neuron·Ko Matsui, Craig E Jahr
Jan 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yo OtsuTimothy H Murphy

❮ Previous
Next ❯

Citations

Oct 24, 2007·Molecular Neurobiology·Wallace B Thoreson
Mar 3, 2009·Molecular Neurobiology·George Zanazzi, Gary Matthews
Oct 22, 2009·Molecular Neurobiology·Annalisa Scimemi, Marco Beato
May 28, 2013·Trends in Neurosciences·Tom BadenLeon Lagnado
Sep 4, 2008·Visual Neuroscience·Qun-Fang WanRuth Heidelberger
Jan 29, 2011·Visual Neuroscience·Qun-Fang Wan, Ruth Heidelberger
Feb 9, 2012·Visual Neuroscience·Jonathan B Demb, Joshua H Singer
Feb 17, 2009·Nature Neuroscience·Skyler L JackmanRichard H Kramer
Aug 12, 2009·Nature Neuroscience·Michael J HigleyBernardo L Sabatini
Jul 26, 2011·Nature Neuroscience·Josefin SnellmanDavid Zenisek
Oct 25, 2011·Nature Neuroscience·Nicholas W Oesch, Jeffrey S Diamond
Nov 4, 2010·Nature Reviews. Neuroscience·Gary Matthews, Paul Fuchs
Jun 10, 2011·Journal of Neurophysiology·Adam A FrancisDavid Zenisek
Nov 20, 2009·Journal of Neurophysiology·Theodore M BartolettiWallace B Thoreson
May 24, 2008·Journal of Neurophysiology·Jerome Petit-Jacques, Stewart A Bloomfield
Mar 7, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Lisamarie LoGiudice, Gary Matthews
Mar 11, 2011·PloS One·Guido A ZampighiNicholas C Brecha
Jun 12, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Geng-Lin LiHenrique von Gersdorff
Aug 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrés E Chávez, Jeffrey S Diamond
May 23, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gary Matthews, Peter Sterling
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tim JarskyJoshua H Singer
Nov 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cole W GraydonHenrique von Gersdorff
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tim JarskyJoshua H Singer
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joshua H SingerAlapakkam P Sampath
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minghui ChenWallace B Thoreson
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katalin RablWallace B Thoreson
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Trisha L KalbaughJeffrey S Diamond
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason M Christie, Craig E Jahr
Mar 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisa GrantElisabeth Glowatzki
May 25, 2010·F1000 Biology Reports·Alapakkam P Sampath, Gordon L Fain
Nov 28, 2013·Annual Review of Physiology·Ling-Gang WuHsueh-Cheng Chiang
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Erica C Keen, A J Hudspeth
Oct 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Juan D Goutman, Elisabeth Glowatzki
Feb 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mark A Rutherford, William M Roberts
Aug 28, 2014·Nature Reviews. Neuroscience·Thomas EulerTom Baden
Jun 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Thirumalini Vaithianathan, Gary Matthews
Dec 4, 2013·The Journal of Physiology·Michael A Freed, Zhiyin Liang
Mar 6, 2013·The Journal of Physiology·Mean-Hwan KimHenrique von Gersdorff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Gary Matthews, P Sterling
Nature Neuroscience
Elisabeth Glowatzki, Paul Fuchs
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jason M Christie, Craig E Jahr
© 2022 Meta ULC. All rights reserved