Coordinated regulation of melatonin synthesis and degradation genes in rice leaves in response to cadmium treatment

Journal of Pineal Research
Yeong ByeonKyoungwhan Back

Abstract

We investigated the expression patterns of genes involved in melatonin synthesis and degradation in rice leaves upon cadmium (Cd) treatment and the subcellular localization sites of melatonin 2-hydroxylase (M2H) proteins. The Cd-induced synthesis of melatonin coincided with the increased expression of melatonin biosynthetic genes including tryptophan decarboxylase (TDC), tryptamine 5-hydroxylase (T5H), and N-acetylserotonin methyltransferase (ASMT). However, the expression of serotonin N-acetyltransferase (SNAT), the penultimate gene in melatonin biosynthesis, was downregulated, suggesting that melatonin synthesis was counter-regulated by SNAT. Notably, the induction of melatonin biosynthetic gene expression was coupled with the induction of four M2H genes involved in melatonin degradation, which suggests that genes for melatonin synthesis and degradation are coordinately regulated. The induced M2H gene expression was correlated with enhanced M2H enzyme activity. Three of the M2H proteins were localized to the cytoplasm and one M2H protein was localized to chloroplasts, indicating that melatonin degradation occurs both in the cytoplasm and in chloroplasts. The biological activity of 2-hydroxymelatonin in the induction of the pl...Continue Reading

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Citations

Mar 1, 2016·Frontiers in Plant Science·Rüdiger Hardeland
Dec 23, 2015·International Journal of Molecular Sciences·Man-Ho Cho, Sang-Won Lee
Mar 2, 2016·Journal of Pineal Research·Hyoung Yool Lee, Kyoungwhan Back
Sep 4, 2015·Journal of Pineal Research·Yeong ByeonKyoungwhan Back
Jun 23, 2015·Journal of Pineal Research·Marino B Arnao, Josefa Hernández-Ruiz
Mar 19, 2016·Journal of Pineal Research·Qiuxiang MaZhen-Yu Wang
Jun 7, 2016·Journal of Pineal Research·Meng-Qi LiJie Zhou
Aug 12, 2016·Frontiers in Plant Science·Haitao ShiChaozu He
Oct 19, 2016·Biotechnology Advances·Lauren A E ErlandPraveen K Saxena
Jan 18, 2017·Journal of Pineal Research·Shu-Yu CaiJie Zhou
Nov 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rüdiger Hardeland
Dec 28, 2017·Journal of Experimental Botany·Yanping WangZhulong Chan
Mar 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun NiLifang Wu
Jan 30, 2020·International Journal of Molecular Sciences·Luying SunXiangnan Li
Mar 12, 2020·Tree Physiology·Ranish ShresthaK C Bhuvan
May 16, 2020·Journal of Experimental Botany·Dun-Xian Tan, Russel J Reiter
Jul 10, 2020·The Plant Journal : for Cell and Molecular Biology·Kyoungwhan Back
Mar 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yi YangHangun Kim
Aug 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yang YuZhiwei Zhao
May 7, 2019·Frontiers in Endocrinology·Dake ZhaoRussel J Reiter
Apr 3, 2020·Biomolecules·Ok Jin HwangKyoungwhan Back
Apr 11, 2019·International Journal of Molecular Sciences·Junpeng LiMin Chen
Dec 11, 2019·International Journal of Molecular Sciences·Ying ZhuXuan Huang

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