Coordination abilities of a fragment containing D1 and H12 residues of neuropeptide gamma and products of metal-catalyzed oxidation

Inorganic Chemistry
T Kowalik-JankowskaFranciszek Kasprzykowski

Abstract

Stoichiometry, stability constants, and solution structures of copper(II) complexes of the (1-2,10-21)NPgamma (D(1)-A(2)-K(10)-R-H(12)-K-T-D-S-F-V-G-L-M(21)-NH(2)) and Ac-(1-2,10-21)NPgamma (Ac-D(1)-A(2)-K(10)-R-H(12)-K-T-D-S-F-V-G-L-M(21)-NH(2)) fragments of neuropeptide gamma were determined in aqueous solution in the pH range 2.5-10.5. The potentiometric and spectroscopic data (UV-vis, CD, EPR) show that an N-terminal Asp residue stabilizes significantly the copper(II) complexes with 1N {NH(2), beta-COO(-)} and 2N {NH(2), beta-COO(-), N(Im)} coordination modes of the (1-2,10-21)NPgamma as the result of coordination through the beta-carboxylate group. In a wide pH range of 4-9, the imidazole nitrogen of His(12) is coordinated to form a macrochelate. The (1-2,10-21)NPgamma peptide consists of 14 amino acid residues and contains an N-terminal amine group and the histidine residue, and as it is suggested, this fragment is able to bind two equivalents of copper(II) ions. The postmortem studies support the involvement of oxidative stress and the production of reactive oxygen species in neurodegenerative diseases. The susceptibility of proteins to oxidative damage is highly dependent on the specific properties of individual protein...Continue Reading

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Citations

Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Narkhyun BaeGert Lubec
Oct 3, 2013·Journal of Inorganic Biochemistry·Marta BłaszakTeresa Kowalik-Jankowska
Apr 10, 2012·Journal of Inorganic Biochemistry·Mariola KuczerTeresa Kowalik-Jankowska
May 4, 2010·Journal of Inorganic Biochemistry·Teresa Kowalik-JankowskaFranciszek Kasprzykowski
Nov 9, 2012·Chemistry : a European Journal·Alessio TravagliaEnrico Rizzarelli
Dec 14, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Elżbieta JankowskaTeresa Kowalik-Jankowska
Jul 20, 2018·Cell Biochemistry and Biophysics·Katerina ChristofidesChristopher E Jones
Nov 6, 2014·Biomolecular Concepts·Takenori Onaga
Dec 7, 2019·Inorganic Chemistry·Shira Ben-ShushanYifat Miller

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