Coordination behavior of new bis Schiff base ligand derived from 2-furan carboxaldehyde and propane-1,3-diamine. Spectroscopic, thermal, anticancer and antibacterial activity studies

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Gehad G MohamedAhmed M M Hindy

Abstract

Novel bis Schiff base ligand, [N1,N3-bis(furan-2-ylmethylene)propane-1,3-diamine], was prepared by the condensation of furan-2-carboxaldehyde with propane-1,3-diamine. Its conformational changes on complexation with transition metal ions [Co(II), Ni(II), Cu(II), Mn(II), Cd(II), Zn(II) and Fe(III)] have been studied on the basis of elemental analysis, conductivity measurements, spectral (infrared, (1)H NMR, electronic), magnetic and thermogravimetric studies. The conductance data of the complexes revealed their electrolytic nature suggesting them as 1:2 (for bivalent metal ions) and 1:3 (for Fe(III) ion) electrolytes. The complexes were found to have octahedral geometry based on magnetic moment and solid reflectance measurements. Thermal analysis data revealed the decomposition of the complexes in successive steps with the removal of anions, coordinated water and bis Schiff base ligand. The thermodynamic parameters were calculated using Coats-Redfern equation. The Anticancer screening studies were performed on human colorectal cancer (HCT), hepatic cancer (HepG2) and breast cancer (MCF-7) cell lines. The antimicrobial activity of all the compounds was studied against Gram negative (Escherichia coli and Proteus vulgaris) and Gram...Continue Reading

References

Mar 22, 2007·Journal of Enzyme Inhibition and Medicinal Chemistry·Balakrishnan Murukan, Kochukittan Mohanan
Apr 14, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·M M OmarAmr A Ibrahim
Apr 27, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Gehad G Mohamed, Madiha H Soliman
Jan 11, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·N RamanA Thamaraichelvan
Dec 18, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Walaa H MahmoudMaher M I El-Dessouky

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Citations

Oct 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui YuHong Liang
May 8, 2020·Anti-cancer Agents in Medicinal Chemistry·Garima Matela

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