Coordination modes of bidentate lornoxicam drug with some transition metal ions. Synthesis, characterization and in vitro antimicrobial and antibreastic cancer activity studies

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Walaa H MahmoudMaher M I el-Dessouky

Abstract

The NSAID lornoxicam (LOR) drug was used for complex formation reactions with different metal salts like Cr(III), Mn(II), Fe(III) and Ni(II) chlorides and Fe(II), Co(II), Cu(II) and Zn(II) borates. Mononuclear complexes of these metals are obtained that coordinated to NO sites of LOR ligand molecule. The nature of bonding and the stereochemistry of the complexes have been deduced from elemental analyses, IR, UV-Vis, (1)H NMR, mass, electronic spectra, magnetic susceptibility and ESR spectral studies, conductivity measurements, thermogravimetric analyses (TG-DTG) and further confirmed by X-ray powder diffraction. The activation thermodynamic parameters are calculated using Coats-Redfern and Horowitz-Metzger methods. The data show that the complexes have composition of ML2 type except for Fe(II) where the type is [ML3]. The electronic absorption spectral data of the complexes suggest an octahedral geometry around the central metal ion for all the complexes. The antimicrobial data reveals that LOR ligand in solution show inhibition capacity less or sometimes more than the corresponding complexes against all the species under study. In order to establish their future potential in biomedical applications, anticancer evaluation studi...Continue Reading

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Apr 20, 2004·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Iffet SakiyanNazmiye Sakiyan
Apr 18, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·M A ZayedNadia E A El-Gamel
Apr 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Irene YoshidaMarcelo Antonio Oliveira
Oct 7, 2010·Journal of Fluorescence·Reeta PunithSeetharamappa Jaldappagari
Dec 20, 2011·Journal of Inorganic Biochemistry·Filitsa DimizaGeorge Psomas
Mar 1, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·M H Soliman, Gehad G Mohamed
Jan 22, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mohammed Mahmmod Al-Ne'aimi, Mohammed Moudar Al-Khuder
Apr 30, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Walid M I HassanSalwa Elramly

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Citations

Nov 5, 2016·International Journal of Biological Macromolecules·Sathi GoswamiMunna Sarkar
Jul 6, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·T A YousefE R El-Rakhawy
Mar 7, 2019·Chemistry : a European Journal·Darya RadziukVladimir Labunov

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