Coordination Modulation Method To Prepare New Metal-Organic Framework-Based CO-Releasing Materials

ACS Applied Materials & Interfaces
Francisco J CarmonaElisa Barea

Abstract

Aluminum-based metal-organic frameworks (MOFs), [Al(OH)(SDC)] n, (H2SDC: 4,4'-stilbenedicarboxylic acid), also known as CYCU-3, were prepared by means of the coordination modulation method to produce materials with different crystal size and morphology. In particular, we screened several reagent concentrations (20-60 mM) and modulator/ligand ratios (0-50), leading to 20 CYCU x_ y materials ( x: reagent concentration, y = modulator/ligand ratio) with different particle size and morphology. Noteworthy, the use of high modulator/ligand ratio gives rise to a new phase of CYCU-3 (CYCU-3' x_50 series), which was structurally analyzed. Afterward, to test the potential of these materials as CO-prodrug carriers, we selected three of them to adsorb the photo- and bioactive CO-releasing molecule (CORM) ALF794 [Mo(CNCMe2CO2H)3(CO)3] (CNCMe2CO2H = 2-isocyano-2-methyl propionic acid): (i) CYCU-3 20_0, particles in the nanometric range; (ii) CYCU-3 50_5, bar-type particles with heterogeneous size, and (iii) CYCU-3' 50_50, a new phase analogous to pristine CYCU-3. The corresponding hybrid materials were fully characterized, revealing that CYCU-3 20_0 with the smallest particle size was not stable under the drug loading conditions. Regarding th...Continue Reading

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Citations

Jan 9, 2020·Chemistry : a European Journal·Stefano CanossaMonique A Van der Veen
Aug 8, 2020·Chemical Communications : Chem Comm·Arnau Carné-SánchezShuhei Furukawa
Feb 10, 2021·Advanced Drug Delivery Reviews·Yingzhu ZhouRona Chandrawati
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Andreia F SilvaMartyn Pillinger
Apr 6, 2020·Chemical Science·Ross S Forgan
Sep 7, 2019·ACS Applied Materials & Interfaces·Upendar Reddy GandraHassan S Bazzi
Dec 1, 2021·Angewandte Chemie·Preecha KittikhunnathamNatalia B Shustova

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