Coordination of Ovulation and Oocyte Maturation: A Good Egg at the Right Time

Endocrinology
Rebecca L RobkerDarryl L Russell

Abstract

Ovulation is the appropriately timed release of a mature, developmentally competent oocyte from the ovary into the oviduct, where fertilization occurs. Importantly, ovulation is tightly linked with oocyte maturation, demonstrating the interdependency of these two parallel processes, both essential for female fertility. Initiated by pituitary gonadotropins, the ovulatory process is mediated by intrafollicular paracrine factors from the theca, mural, and cumulus granulosa cells, as well as the oocyte itself. The result is the induction of cumulus expansion, proteolysis, angiogenesis, inflammation, and smooth muscle contraction, which are each required for follicular rupture. These complex intercellular communication networks and the essential ovulatory genes have been well defined in mouse models and are highly conserved in primates, including humans. Importantly, recent discoveries in regulation of ovulation highlight new areas of investigation.

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Citations

Jan 14, 2019·Reproduction, Fertility, and Development·Elizabeth G BromfieldMichael J Bertoldo
Jan 22, 2020·American Journal of Physiology. Endocrinology and Metabolism·Fuxin WangPeter C K Leung
Mar 18, 2020·International Journal of Molecular Sciences·Stefano BaroneAntonio Musio
Dec 4, 2019·Frontiers in Endocrinology·Hannah R BenderDiane M Duffy
Mar 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao LiangYan-Cang Duan
May 13, 2020·American Journal of Reproductive Immunology : AJRI·Ziwei YangYuehui Zheng
Aug 6, 2020·International Journal of Molecular Sciences·Emma R JamesAlbert Salas-Huetos
Mar 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jennifer McKeyBlanche Capel
Oct 18, 2020·International Journal of Molecular Sciences·Jana JankovičováJana Antalíková
Nov 6, 2020·Biochemistry Research International·Shaoyuan XuBeiyu Liu
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Alexander A TokmakovKen-Ichi Sato
Mar 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Genevieve E CampbellDiane M Duffy
Dec 9, 2020·Molecular Aspects of Medicine·Camilla H K Hughes, Bruce D Murphy
Feb 23, 2021·JCI Insight·Sweta RavisankarJon D Hennebold
May 11, 2021·Journal of Assisted Reproduction and Genetics·Alexander M Quaas
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Liang LiQing Zhu
Jul 25, 2021·International Journal of Molecular Sciences·Alexander G Kuzma-HuntLaura A Favetta
Jul 29, 2021·Cell Death & Disease·Zhong-Xin JiangWen Li
Aug 16, 2021·Ecotoxicology and Environmental Safety·Si-Cheng ZhaoYu Liu
Dec 4, 2021·Journal of Cellular and Molecular Medicine·Qiaojuan MeiWenpei Xiang

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