Coordination of size and number of excitatory and inhibitory synapses results in a balanced structural plasticity along mature hippocampal CA1 dendrites during LTP.

Hippocampus
Jennifer N Bourne, Kristen M Harris

Abstract

Enlargement of dendritic spines and synapses correlates with enhanced synaptic strength during long-term potentiation (LTP), especially in immature hippocampal neurons. Less clear is the nature of this structural synaptic plasticity on mature hippocampal neurons, and nothing is known about the structural plasticity of inhibitory synapses during LTP. Here the timing and extent of structural synaptic plasticity and changes in local protein synthesis evidenced by polyribosomes were systematically evaluated at both excitatory and inhibitory synapses on CA1 dendrites from mature rats following induction of LTP with theta-burst stimulation (TBS). Recent work suggests dendritic segments can act as functional units of plasticity. To test whether structural synaptic plasticity is similarly coordinated, we reconstructed from serial section transmission electron microscopy all of the spines and synapses along representative dendritic segments receiving control stimulation or TBS-LTP. At 5 min after TBS, polyribosomes were elevated in large spines suggesting an initial burst of local protein synthesis, and by 2 h only those spines with further enlarged synapses contained polyribosomes. Rapid induction of synaptogenesis was evidenced by an ...Continue Reading

References

Sep 1, 1989·Journal of Neuroscience Methods·F E Jensen, K M Harris
Nov 22, 1986·The Journal of Comparative Neurology·N L Desmond, W B Levy
Dec 1, 1987·Brain Research·G BuzsákiE G Anderson
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·P A Buchs, D Muller
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Feb 6, 1997·Nature·U Frey, R G Morris
Jul 8, 1999·Current Opinion in Neurobiology·K M Harris
Sep 24, 1999·Nature Neuroscience·S A Kirov, K M Harris
Feb 19, 2000·Current Opinion in Neurobiology·D G WellsJ R Fallon
Mar 17, 2000·Neuron·J W Lichtman, H Colman
Jan 6, 2001·Journal of the American Medical Informatics Association : JAMIA·J C Fiala, K M Harris
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M YankovaC S Woolley
Apr 3, 2001·Annual Review of Neuroscience·O Steward, E M Schuman
Jun 27, 2001·Nature Neuroscience·S S ZakharenkoS A Siegelbaum
Aug 25, 2001·Annual Review of Neuroscience·R Yuste, T Bonhoeffer
Sep 6, 2001·Journal of Neurophysiology·S L Morgan, T J Teyler
Dec 12, 2001·Nature Neuroscience·D R GrosshansM D Browning
Feb 8, 2002·Neuron·György Buzsáki

❮ Previous
Next ❯

Citations

Nov 29, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Bai-liu YaBo Bai
May 15, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Javier Cortés-MendozaLeonor Pérez-Martínez
Aug 1, 2013·Nature Reviews. Neuroscience·Cyril Hanus, Erin M Schuman
Oct 30, 2013·The Journal of Cell Biology·Nathalia Vitureira, Yukiko Goda
Feb 16, 2013·Molecular Brain·Magdalena Sanhueza, John Lisman
Jun 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kea Joo LeeIm Joo Rhyu
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shannon L GourleyAnthony J Koleske
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yu-Chih LinAnthony J Koleske
Aug 18, 2012·Neural Plasticity·Milan Fedurco
Mar 19, 2014·Psychoneuroendocrinology·Marlena Wosiski-KuhnAlexis M Stranahan
Feb 24, 2012·Cold Spring Harbor Perspectives in Biology·Kristen M Harris, Richard J Weinberg
Apr 8, 2016·Cellular Logistics·Sharon A SwangerJeremy H Herskowitz
Jan 23, 2016·Frontiers in Neural Circuits·Christoph HartmannJochen Triesch
Jan 26, 2016·Nature Reviews. Neuroscience·Paul SmolenJohn H Byrne
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ana C PereiraJohn H Morrison
Dec 1, 2015·ELife·Thomas M BartolTerrence J Sejnowski
Feb 26, 2016·Nature Neuroscience·Rishidev Chaudhuri, Ila Fiete
Jan 29, 2016·Neural Plasticity·Malgorzata JasinskaMalgorzata Kossut
Mar 31, 2015·European Journal of Pharmacology·Mónica SantosMara Dierssen
Sep 30, 2015·Hippocampus·Deborah J WatsonKristen M Harris
Mar 2, 2012·Hippocampus·Charles Y ShaoTodd Charlton Sacktor
Feb 9, 2012·The Journal of Comparative Neurology·Aniruddha YadavChristina M Weaver
Nov 3, 2015·Nature Neuroscience·Sukbin LimNicolas Brunel
Oct 22, 2013·Mechanisms of Ageing and Development·Erlend A NagelhusTone Tønjum
Jul 22, 2014·The Journal of Comparative Neurology·Maria Elizabeth BellKristen M Harris
Apr 29, 2015·Alcoholism, Clinical and Experimental Research·Mary-Louise RisherH S Swartzwelder
Dec 17, 2014·Brain Research·John Lisman, Sridhar Raghavachari
Aug 4, 2015·Nature Neuroscience·J WittonM W Jones
Aug 11, 2015·Frontiers in Computational Neuroscience·Kristofer E BouchardMichael S Brainard
Jun 23, 2015·Nature·Alessio AttardoMark J Schnitzer
Jul 8, 2015·Frontiers in Computational Neuroscience·Julio ChapetonArmen Stepanyants

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.