Coordination polymer nanocapsules prepared using metal-organic framework templates for pH-responsive drug delivery

Nanotechnology
Lei TangZhongyi Jiang

Abstract

A facile, efficient, and versatile approach is presented to synthesize pH-responsive nanocapsules (∼120 nm) by combining the advantages of metal-organic frameworks (MOFs) and metal-organic thin films. ZIF-8 nanoparticles are used as templates on which a thin film coating of iron(III)-catechol complexes is derived from the coordination between dopamine-modified alginate (AlgDA) and iron(III) ions. After the template removal, nanocapsules with a pH-responsive wall are obtained. Doxorubicin (Dox), a typical anticancer drug, is first immobilized in ZIF-8 frameworks through coprecipitation and then encapsulated in nanocapsules after the removal of ZIF-8. The structure of the iron(III)-catechol complex varies with pH value, thus conferring the Dox@Nanocapsules with tailored release behavior in vitro. Cytotoxicity tests illustrate the highly effective cytotoxicity of Dox@Nanocapsules towards cancer cells. This study provides a new method for preparing smart nanocapsules and offers more opportunities for the controlled delivery of drugs.

References

Apr 13, 2006·Journal of the American Chemical Society·Hideki SakaiMasahiko Abe
Jan 30, 2007·Nature Materials·Tapas Kumar MajiSusumu Kitagawa
Apr 23, 2009·Chemical Society Reviews·Alexander M SpokoynyChad A Mirkin
Jul 30, 2009·Journal of the American Chemical Society·Hai-Long JiangQiang Xu
Nov 19, 2009·Journal of the American Chemical Society·Chiyoung ParkChulhee Kim
Mar 6, 2010·Science·Matthew J HarringtonPeter Fratzl
May 27, 2010·Journal of the American Chemical Society·Wenwen LiKrzysztof Matyjaszewski
Jul 24, 2010·Angewandte Chemie·Alistair C McKinlayChristian Serre
Nov 26, 2010·Chemical Society Reviews·Arnau CarnéDaniel Maspoch
Dec 15, 2010·Angewandte Chemie·Xiao-Chao YangVincent M Rotello
Feb 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Niels Holten-AndersenJ Herbert Waite
Jun 9, 2011·Accounts of Chemical Research·Joseph Della RoccaWenbin Lin
Sep 21, 2011·Chemical Reviews·Angélique Bétard, Roland A Fischer
Mar 22, 2012·Journal of the American Chemical Society·Demetra S AchilleosMaria Vamvakaki
Apr 22, 2014·Chemistry of Materials : a Publication of the American Chemical Society·Hongyu ChenJeffrey N Anker
Sep 10, 2014·Angewandte Chemie·Qiang WeiRainer Haag
Oct 14, 2014·Chemical Society Reviews·Yu ZhangJohn Wang

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Citations

Mar 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhixian LeiZian Lin
Nov 3, 2020·Chemical Society Reviews·Ricardo F MendesFilipe A Almeida Paz
Apr 23, 2020·Pharmaceutical Nanotechnology·Benjamin Steinborn, Ulrich Lächelt
Oct 12, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiangdong XueYuanpei Li
Nov 11, 2019·ACS Biomaterials Science & Engineering·Junling GuoHirotaka Ejima

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