PMID: 16629168Apr 25, 2006Paper

Cop-like operon: structure and organization in species of the Lactobacillale order

Biological Research
Angélica ReyesMauricio Gonzalez

Abstract

Copper is an essential and toxic trace metal for bacteria and, therefore, must be tightly regulated in the cell. Enterococcus hirae is a broadly studied model for copper homeostasis. The intracellular copper levels in E. hirae are regulated by the cop operon, which is formed by four genes: copA and copB that encode ATPases for influx and efflux of copper, respectively; copZ that encodes a copper chaperone; and copY, a copper responsive repressor. Since the complete genome sequence for E. hirae is not available, it is possible that other genes may encode proteins involved in copper homeostasis. Here, we identified a cop-like operon in nine species of Lactobacillale order with a known genome sequence. All of them always encoded a CopY-like repressor and a copper ATPase. The alignment of the cop-like operon promoter region revealed two CopY binding sites, one of which was conserved in all strains, and the second was only present in species of Streptococcus genus and L. johnsonii. Additional proteins associated to copper metabolism, CutC and Cupredoxin, also were detected. This study allowed for the description of the structure and organization of the cop operon and discussion of a phylogenetic hypothesis based on the differences o...Continue Reading

Citations

May 27, 2010·Foodborne Pathogens and Disease·Raghavendra G AmachawadiT G Nagaraja
May 12, 2009·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Miriam Moscoso, Ernesto García
Mar 11, 2009·Antimicrobial Agents and Chemotherapy·Petra BeckerBernhard Henrich
Sep 26, 2006·Applied and Environmental Microbiology·S PenaudM van de Guchte
Sep 2, 2009·Microbiology and Molecular Biology Reviews : MMBR·Angela H NobbsHoward F Jenkinson
Jun 26, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Angélica Reyes-JaraMauricio González
Mar 3, 2011·Biochemical and Biophysical Research Communications·Mauricio LatorreMauricio González
Apr 24, 2015·Metallomics : Integrated Biometal Science·Mauricio LatorreMauricio González
Jan 3, 2014·Metallomics : Integrated Biometal Science·Mauricio LatorreMauricio González
Jan 23, 2015·Metallomics : Integrated Biometal Science·Zhong GuoXuesong Sun
Jan 30, 2021·FEMS Microbiology Ecology·Almudena Escobar-NiñoDavid Cánovas
May 31, 2021·Veterinary Microbiology·Wei PengWeicheng Bei
Apr 21, 2018·Microbiology Spectrum·Christopher RensingSylvia Franke McDevitt

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