Copanlisib: An Intravenous Phosphatidylinositol 3-Kinase (PI3K) Inhibitor for the Treatment of Relapsed Follicular Lymphoma

The Annals of Pharmacotherapy
Adel EltantawyKirsten Evans

Abstract

Objective: To review the mechanism of action, clinical efficacy, safety, dosage, administration, and role of copanlisib in the treatment of relapsed follicular lymphoma (FL). Data Sources: Sources of information were identified through searches of PubMed (August 2014 to January 2019) using the key terms copanlisib, Aliqopa, PI3K inhibitor, and BAY 80-6946. Unpublished abstract information was obtained from the American Society of Clinical Oncology. Study Selection and Data Extraction: Review articles and studies in the English language evaluating the pharmacology, efficacy, and safety of copanlisib were included. Data Synthesis: Copanlisib is the first intravenous phosphatidylinositol 3-kinase (PI3K) inhibitor approved for the treatment of relapsed FL in patients who have received at least 2 prior systemic therapies. The safety and efficacy of copanlisib has been studied in the multicenter, single-arm, phase II CHRONOS-1 study. The results reported for FL patients were an objective response rate of 59%, a complete response of 14%, median duration of response of 22.6 months, and median progression-free survival of 11.2 months. The most common adverse events reported were hyperglycemia and hypertension, which were infusion relate...Continue Reading

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Citations

Jan 21, 2020·Pharmacology Research & Perspectives·Yu CaiTadimeti S Rao
Sep 22, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Olivia G FaheyElizabeth N Dow-Hillgartner
Feb 29, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Daniel A HeschelerHakan Alakus
Oct 5, 2020·Life Sciences·Sadegh FattahiHaleh Akhavan-Niaki
Mar 7, 2021·Cancers·Chiara PediconeWilliam G Kerr
Mar 29, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Roskoski

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