COPD as a systemic disease: impact on physical functional limitations.

The American Journal of Medicine
M D EisnerC Iribarren

Abstract

Although chronic obstructive pulmonary disease (COPD) has a major impact on physical health, the specific impact of COPD on physical functional limitations has not been characterized clearly. We aimed to elucidate the physical functional limitations that are directly attributable to COPD compared to a matched referent group without the condition. We used the Function, Living, Outcomes, and Work (FLOW) cohort study of adults with COPD (n=1202) and referent subjects matched by age, sex, and race (n=302) to study the impact of COPD on the risk of a broad array of functional limitations using validated measures: lower extremity function (Short Physical Performance Battery [SPPB]), submaximal exercise performance (Six Minute Walk Test [SMWT]), standing balance (Functional Reach Test), skeletal muscle strength (manual muscle testing with dynamometry), and self-reported functional limitation (standardized item battery). Multivariate analysis was used to control for confounding by age, sex, race, height, educational attainment, and cigarette smoking. COPD was associated with poorer lower extremity function (mean SPPB score decrement for COPD vs referent -1.0 points; 95% CI, -1.25 to -0.73 pts) and less distance walked during the SMWT (...Continue Reading

References

Apr 3, 1976·British Medical Journal·C R McGavinG J McHardy
Mar 1, 1992·Journal of the American Geriatrics Society·D K WeinerS A Studenski
May 1, 1992·Journal of Gerontology·P W DuncanB Prescott
Nov 1, 1990·Journal of Gerontology·P W DuncanS Studenski
Jul 1, 1989·International Disability Studies·S J Williams, M R Bury
Nov 1, 1987·The American Review of Respiratory Disease·A S Buist
Mar 1, 1984·The Journal of Hand Surgery·V MathiowetzN Kashman
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Mar 2, 1995·The New England Journal of Medicine·J M GuralnikR B Wallace
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·M DecramerP Rogiers
Jan 1, 1994·Social Science & Medicine·L M Verbrugge, A M Jette
Aug 1, 1993·Archives of Physical Medicine and Rehabilitation·D K WeinerG G Kochersberger
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·A L HamiltonN L Jones
May 16, 1998·American Journal of Public Health·B RockhillC Weinberg
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·S BernardF Maltais
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Jan 23, 2002·Journal of Occupational and Environmental Medicine·Gershon FinkMordechai R Kramer
May 22, 2002·JAMA : the Journal of the American Medical Association·Andrew J KarterJoe V Selby
Jul 29, 2003·The European Respiratory Journal·L M FabbriUNKNOWN GOLD Scientific Committee
Sep 27, 2006·The American Journal of Medicine·Mark D EisnerPaul D Blanc
Nov 14, 2006·Chest·Carolyn S CalfeeMark D Eisner
Feb 16, 2007·Annals of Epidemiology·Mark D EisnerIra B Tager
Sep 4, 2007·Lancet·A Sonia BuistUNKNOWN BOLD Collaborative Research Group
Sep 4, 2007·Lancet·Leonardo M Fabbri, Klaus F Rabe

❮ Previous
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Citations

Sep 27, 2012·JAMA : the Journal of the American Medical Association·Terri R FriedMichael W Rabow
Jul 20, 2011·Zeitschrift für Gerontologie und Geriatrie·H FrohnhofenC Falkenhahn
Jan 11, 2012·Current Opinion in Pulmonary Medicine·Francesco LandiFabrizia Lattanzio
Nov 3, 2010·Journal of Cardiopulmonary Rehabilitation and Prevention·Marc RoigWendy D Reid
Jan 18, 2011·Journal of Cardiopulmonary Rehabilitation and Prevention·Jonathan SingerPaul D Blanc
Oct 27, 2009·Journal of Epidemiology and Community Health·M D EisnerC Iribarren
Mar 26, 2010·Thorax·Mark D EisnerTheodore A Omachi
Jun 13, 2012·Respiration; International Review of Thoracic Diseases·Jonathan P SingerPaul D Blanc
May 9, 2009·American Journal of Respiratory and Critical Care Medicine·William W HungJoseph S Ross
Jan 1, 2010·Multidisciplinary Respiratory Medicine·Maria K BeauchampRoger S Goldstein
Jun 15, 2010·Medicine and Science in Sports and Exercise·Mary C KapellaCharles G Alex
Sep 22, 2010·International Journal of Chronic Obstructive Pulmonary Disease·Neeta ThakurMark D Eisner
Oct 25, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Paul JonesKaroly Kulich
Feb 23, 2013·International Journal of Chronic Obstructive Pulmonary Disease·Sonja M BjerkKen M Kunisaki
Jun 12, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Mark D EisnerPaul D Blanc
Jul 28, 2013·American Journal of Respiratory and Critical Care Medicine·Lies LahousseGuy G Brusselle
Jan 30, 2014·European Journal of Internal Medicine·Ernesto CrisafulliEnrico M Clini
Aug 15, 2012·Journal of General Internal Medicine·Theodore A OmachiPatricia P Katz
Nov 15, 2013·Expert Review of Respiratory Medicine·Regina W M LeungJennifer A Alison
Oct 6, 2009·Chest·Camila F RizziDalva Poyares
Nov 26, 2011·Chest·Marla K BeauchampDina Brooks
Jul 17, 2012·The Medical Clinics of North America·Jonathan P Singer, Roger D Yusen
Aug 11, 2015·American Journal of Respiratory and Critical Care Medicine·Jonathan P SingerDavid J Lederer
Sep 8, 2015·Respiratory Medicine·Lies LahousseGuy G Brusselle
Nov 5, 2014·International Journal of Clinical Practice·T WelteA Papi
Aug 31, 2010·Archives of Physical Medicine and Rehabilitation·Marla K BeauchampDina Brooks
Nov 4, 2010·Archives of Physical Medicine and Rehabilitation·Rebecca WongDina Brooks
Jan 10, 2014·Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses·Abbas HeydariSeyed-hossein Ahmadi hosseini
May 4, 2015·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Roxanne E JensenCarol M Moinpour
Mar 16, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Susan E YountAlan Hamilton

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