COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species

Respirology : Official Journal of the Asian Pacific Society of Respirology
Jodie L SimpsonPhilip M Hansbro

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and inflammation. Airway bacterial colonization is increased in COPD; however, the role of potentially pathogenic and non-pathogenic bacteria in the pathogenesis of disease is unclear. This study characterized the presence of bacteria in a well-characterized cohort of adults with COPD and healthy controls. Adults with COPD (n = 70) and healthy controls (n = 51) underwent clinical assessment and sputum induction. Sputum was dispersed, and total and differential cell counts were performed. Bacteria were cultured, identified and enumerated. Supernatants were assessed for neutrophil elastase (NE) and IL-1β. Common respiratory pathogens were also determined using real-time PCR. Participants with COPD had a typical neutrophilic inflammatory profile. The total load of bacteria was increased in COPD and was associated with poorer respiratory health status, as measured by the St George's Respiratory Questionnaire (Spearman's r = 0.336, P = 0.013). Significantly lower levels of culturable Bacillus species were identified compared with healthy controls. PCR analyses revealed increased rates of detection of potentially pathogenic bacteria with H...Continue Reading

References

Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·P G GibsonR L Clancy
Aug 16, 2002·The New England Journal of Medicine·Sanjay SethiTimothy F Murphy
Apr 10, 2003·American Journal of Respiratory and Critical Care Medicine·Tom M A WilkinsonJadwiga A Wedzicha
Feb 26, 2004·The European Respiratory Journal·J A PrestonP M Hansbro
Jun 5, 2004·The European Respiratory Journal·D BanerjeeD Honeybourne
Aug 6, 2004·The European Respiratory Journal·M A BirrellM G Belvisi
Apr 19, 2007·FEMS Immunology and Medical Microbiology·Tanya CurranWilson A Coulter
Sep 4, 2007·Lancet·A Sonia BuistUNKNOWN BOLD Collaborative Research Group
Aug 1, 2009·The European Respiratory Journal·A MarinJ Morera
Jun 8, 2010·The European Respiratory Journal·J A PrestonP M Hansbro
Jul 6, 2010·American Journal of Respiratory and Critical Care Medicine·Alvar Agusti, Peter J Barnes
Mar 3, 2011·PloS One·John R Erb-DownwardGary B Huffnagle
Aug 26, 2011·The New England Journal of Medicine·Richard K AlbertUNKNOWN COPD Clinical Research Network
Oct 15, 2011·PLoS Pathogens·Ama-Tawiah EssilfiePhilip M Hansbro
Mar 31, 2012·COPD·Alicia MarinUNKNOWN PAC-COPD Study Group
Oct 17, 2012·PloS One·Alexa A PragmanRichard E Isaacson
Feb 6, 2013·The Journal of Allergy and Clinical Immunology·Emma L BeckettPhilip M Hansbro
Apr 10, 2013·Current Opinion in Pharmacology·Malcolm Ronald StarkeyPhilip Michael Hansbro
Jan 16, 2014·Annals of the American Thoracic Society·Himanshu DesaiSanjay Sethi
Apr 24, 2014·Expert Opinion on Drug Discovery·Michael FrickerPhilip M Hansbro
May 23, 2014·Journal of Clinical Microbiology·Yvonne J HuangSusan V Lynch
Jun 29, 2014·Immunology Letters·Kamran Haq, Janet E McElhaney
Mar 10, 2015·American Journal of Respiratory and Critical Care Medicine·Alan Chen-Yu HsuPhilip M Hansbro

❮ Previous
Next ❯

Citations

May 14, 2016·Human Vaccines & Immunotherapeutics·Marina Cerquetti, Maria Giufrè
Jan 20, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sanjay H ChotirmallPhilip M Hansbro
May 13, 2017·The International Journal of Biochemistry & Cell Biology·Md Khadem AliJay C Horvat
Oct 5, 2018·Journal of Leukocyte Biology·Caroline M PercopoHelene F Rosenberg
Aug 3, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jodie L Simpson
Oct 31, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shakti D ShuklaPhilip M Hansbro
Mar 28, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Janice M LeungSanjay H Chotirmall
Jul 20, 2019·The European Respiratory Journal·Kylie B R BelchamberUNKNOWN COPD-MAP consortium
Aug 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katrin RichterVeronika Grau
Apr 4, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tow Keang LimJudith Mak
May 14, 2019·Expert Opinion on Therapeutic Targets·Gaetano CaramoriIan M Adcock
Apr 25, 2017·Clinical & Translational Immunology·Shakti D ShuklaPhilip M Hansbro
Oct 7, 2020·Biology·Luigi SantacroceSkender Topi
Oct 13, 2020·Frontiers in Medicine·Keshav Raj PaudelPhilip M Hansbro
Feb 19, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Xiaofan TuPhilip M Hansbro
Jul 25, 2021·International Journal of Molecular Sciences·Stanislav Kotlyarov, Anna Kotlyarova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.