Copeptin in the diagnosis of vasopressin-dependent disorders of fluid homeostasis

Nature Reviews. Endocrinology
Mirjam Christ-Crain, Wiebke Fenske

Abstract

Copeptin and arginine vasopressin (AVP) are derived from a common precursor molecule and have equimolar secretion and response to osmotic, haemodynamic and stress-related stimuli. Plasma concentrations of copeptin and AVP in relation to serum osmolality are highly correlated. The physiological functions of AVP with respect to homeostasis of fluid balance, vascular tonus and regulation of the endocrine stress response are well known, but the exact function of copeptin is undetermined. Quantification of AVP can be difficult, but copeptin is stable in plasma and can be easily measured with a sandwich immunoassay. For this reason, copeptin has emerged as a promising marker for the diagnosis of AVP-dependent fluid disorders. Copeptin measurements can enable differentiation between various conditions within the polyuria-polydipsia syndrome. In the absence of prior fluid deprivation, baseline copeptin levels >20 pmol/l identify patients with nephrogenic diabetes insipidus. Conversely, copeptin levels measured upon osmotic stimulation differentiate primary polydipsia from partial central diabetes insipidus. In patients with hyponatraemia, low levels of copeptin together with low urine osmolality identify patients with primary polydipsi...Continue Reading

Associated Clinical Trials

References

May 1, 1976·The Journal of Clinical Investigation·G Baumann, J F Dingman
Apr 19, 1991·Journal of Chromatography·B J Van de HeijningT B Van Wimersma Greidanus
Feb 29, 1988·Biochemical and Biophysical Research Communications·G NagyJ D Neill
Jan 1, 1988·Social Science & Medicine·J M HillS D Dorsey
Nov 1, 1987·The American Journal of Medicine·H M ChungR J Anderson
Oct 1, 1973·The Journal of Clinical Endocrinology and Metabolism·M K HusainS M Glick
Nov 1, 1970·Annals of Internal Medicine·M MillerD H Streeten
Mar 1, 1968·The Journal of Clinical Investigation·A R Harrington, H Valtin
Aug 1, 1980·Pflügers Archiv : European journal of physiology·F T LaRochelleP Stern
Jan 1, 1980·Annual Review of Medicine·R ZerbeG Robertson
Apr 16, 1998·Cellular and Molecular Neurobiology·F M de Bree, J P Burbach
Jul 31, 1998·Lancet·S Kumar, T Berl
Aug 31, 2000·Annual Review of Biochemistry·A J Parodi
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·D SmithC J Thompson
Jan 9, 2003·Trends in Biochemical Sciences·Joseph D SchragJohn J M Bergeron
Mar 14, 2003·Clinical Biochemistry·M Jane EllisMargaret J Evans
Jul 24, 2003·American Journal of Physiology. Renal Physiology·Melissa A CadnapaphornchaiRobert W Schrier
Oct 1, 1957·The Journal of Clinical Investigation·R W BERLINER, D G DAVIDSON
Apr 1, 1961·Annals of Internal Medicine·F DIESA RIVERA
Aug 31, 1963·JAMA : the Journal of the American Medical Association·A M DASHED H SOLOMON
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Joseph G Verbalis
Nov 5, 2005·Clinical Chemistry·Nils G MorgenthalerAndreas Bergmann
Jan 13, 2006·European Journal of Clinical Investigation·J J PuderU Keller
Jan 25, 2006·The American Journal of Medicine·Benoit RenneboogGuy Decaux
Jan 1, 1997·Platelets·T Wun
Jul 18, 2006·The American Journal of Medicine·Ashish UpadhyayNicolaos E Madias
Sep 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sorana Ciura, Charles W Bourque
Nov 16, 2006·The New England Journal of Medicine·Robert W SchrierUNKNOWN SALT Investigators
Apr 12, 2007·The Journal of Clinical Endocrinology and Metabolism·Mira KatanMirjam Christ-Crain
Nov 22, 2007·The American Journal of Medicine·Joseph G VerbalisRichard H Sterns
May 15, 2008·The Journal of Clinical Endocrinology and Metabolism·Wiebke FenskeBruno Allolio

❮ Previous
Next ❯

Citations

Aug 18, 2016·Frontiers in Pediatrics·Katrina Suzanne Evers, Sven Wellmann
Nov 3, 2016·Developmental Neurobiology·Meghan A LockardCornelia I Bargmann
Jun 9, 2017·European Heart Journal. Acute Cardiovascular Care·Christian MuellerUNKNOWN ESC Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association
Jun 24, 2017·Clinical Hypertension·Baris Afsar
May 31, 2017·Clinical Endocrinology·Clara O SailerMirjam Christ-Crain
Sep 18, 2018·Physiological Reports·Michael J StaceySimon K Delves
Jan 8, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Shouguo GaoNatalia I Dmitrieva
Aug 15, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·William PedrosaAntônio Ribeiro-Oliveira
Jul 24, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Renfei LuoChunling Li
Jan 4, 2019·PloS One·Astrid PechmannBarbara Zieger
Nov 21, 2018·Critical Reviews in Clinical Laboratory Sciences·Magnus Nakrem LyngbakkenTorbjørn Omland
Feb 9, 2017·Journal of the American Society of Nephrology : JASN·Ewout J Hoorn, Robert Zietse
Mar 12, 2019·Expert Review of Proteomics·Eleni PetraAntonia Vlahou
Sep 23, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·C Lundegaard AsfergJ L Jeppesen
Jun 13, 2019·International Urology and Nephrology·Maciej FijałkowskiEdyta Golembiewska
Jun 14, 2020·Clinical Endocrinology·Bettina WinzelerMirjam Christ-Crain
Dec 29, 2018·Endocrine Connections·Julie RefardtMirjam Christ-Crain
Aug 19, 2020·European Journal of Pediatrics·Gerdi TuliLuisa de Sanctis
Nov 20, 2016·Clinical Endocrinology·Ewout J Hoorn
Aug 2, 2018·The New England Journal of Medicine·Wiebke FenskeMirjam Christ-Crain
Aug 2, 2019·Journal of Endocrinological Investigation·M Christ-Crain, W K Fenske
Dec 11, 2019·Translational Psychiatry·Nichola M BrydgesJeremy Hall
Aug 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Marie-Anne BurckhardtGabor Szinnai
Aug 28, 2020·Pituitary·Juliana B DrummondAntonio Ribeiro-Oliveira
Jul 14, 2020·Internal Medicine Journal·Lisa K Bichard, David J Torpy
Aug 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Jorien Werumeus BuningAndré P van Beek
Dec 22, 2017·The Journal of Clinical Endocrinology and Metabolism·Wiebke K FenskeMirjam Christ-Crain
Jan 22, 2020·American Journal of Physiology. Renal Physiology·Clara Odilia SailerMirjam Christ-Crain
Apr 30, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Peter JanssensDjalila Mekahli
Oct 28, 2017·European Journal of Applied Physiology·Michael John StaceyDavid R Woods
Jul 13, 2019·Frontiers in Endocrinology·Ferenc A Antoni
Dec 29, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Niels S HeinrichPeter Rossing
Jan 12, 2021·Curēus·Gagan PriyaEmmy Grewal
Feb 12, 2021·Journal of Medical Virology·Mutlu KuluöztürkAyşegül Altıntop Geçkil

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.