Copeptin role in polyuria-polydipsia syndrome differential diagnosis and reference range in paediatric age

Clinical Endocrinology
Gerdi TuliLuisa De Sanctis

Abstract

Plasma arginine-vasopressin (AVP) analysis can help in the differential diagnosis of the polyuria-polydipsia syndrome (PPS), even if such investigation is hampered by technical difficulties, conversely to its surrogate copeptin. This study aims to enlarge the existing data on normal copeptin levels in childhood, to evaluate the correlation between copeptin, serum sodium and plasma and urine osmolality, and to assess the utility of the copeptin analysis in the diagnostic work-up of PPS in the paediatric age. Plasma copeptin levels were evaluated in 53 children without AVP disorders (control population), in 12 hypopituitaric children and in 15 patients with PPS after water deprivation test (WDT). Mean basal copeptin levels were 5.2 ± 1.56 (range 2.4-8.6 pmol/L) in the control population, 2.61 ± 0.49 pmol/L in the hypopituitaric children with complete diabetes insipidus (CDI) (P = .04) and 6.21 ± 1.17 pmol/L in the hypopituitaric patients without DI (P = .02). After WDT, among 15 naïve polyuric/polydipsic children, copeptin values greater than 20 pmol/L allowed to identify nephrogenic diabetes insipidus (NDI), concentrations below 2.2 pmol/L complete central DI (CCDI) and between 5 and 20 pmol/L primary polydipsia (PP). Copeptin c...Continue Reading

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Citations

Aug 28, 2020·Pituitary·Juliana B DrummondAntonio Ribeiro-Oliveira
Aug 19, 2020·European Journal of Pediatrics·Gerdi TuliLuisa de Sanctis
Nov 4, 2020·Molecular and Cellular Pediatrics·Gerhard BinderJoachim Woelfle
Dec 8, 2020·The Annals of Thoracic Surgery·Erhan UrganciClaudia Herbst
Jul 23, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Letícia BitencourtAna Cristina Simões E Silva
Apr 3, 2021·Pediatrics·Jane E DrianoAna L Creo

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