Copolymer-cyclodextrin inclusion complexes in water and in the solid state. A physico-chemical study

The Journal of Physical Chemistry. B
G Lazzara, S Milioto

Abstract

The formation of inclusion complexes (ICs) composed of cyclodextrins (CDs) and poly(ethylene oxides)-poly(propylene oxides)-poly(ethylene oxides) (PEO-PPO-PEO) was studied. To this purpose, native and hydroxypropyl cyclodextrins with different cavity size were chosen. The PEO-PPO-PEO copolymers were selected to study the role of the molecular weight, keeping constant the hydrophilic/hydrophobic ratio, and the hydrophilicity. The volumetric studies at 25 degrees C allowed to determine the equilibrium constant and the volume change for the IC formation in water as well as the IC stoichiometry. Surface tension experiments evidenced that the copolymer and the CD interfacial behavior is controlled by the formation of ICs taking place in the bulk phase. It was proved that the differential scanning calorimetry (DSC) is a valid method to describe quantitatively the IC in the solid state. The combination of volumes, DSC and FTIR techniques together with the geometric information highlighted the following points: (1) the included copolymer is in the amorphous state; (2) the IC composed of native CDs adopts a channel structure with two EO units incorporated into one CD molecule; (3) the IC composed of hydroxypropyl-cyclodextrin is a polym...Continue Reading

References

Jan 14, 1999·Journal of Colloid and Interface Science·C GuoJ Chen
Feb 19, 2002·Chemical Reviews·József Szejtli
Feb 19, 2002·Chemical Reviews·Mikhail V. Rekharsky, Yoshihisa Inoue
Nov 18, 2005·Journal of Colloid and Interface Science·Yan-Lei SuHui-Zhou Liu
Mar 9, 2006·Chemical Reviews·Gerhard WenzAxel Müller
Jun 20, 2006·Journal of Colloid and Interface Science·Ligia GargalloDeodato Radić
Jan 11, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Julie JosephJan Skov Pedersen
Mar 30, 2007·The Journal of Physical Chemistry. B·Marcus A HuntC Maurice Balik

❮ Previous
Next ❯

Citations

May 28, 2013·International Journal of Pharmaceutics·Agnese MiroFabiana Quaglia
Jan 14, 2016·Physical Chemistry Chemical Physics : PCCP·Pronab KunduNitin Chattopadhyay
Jun 9, 2015·Soft Matter·Anis Abdul Karim, Xian Jun Loh
Mar 19, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Gustavo González-GaitanoCécile A Dreiss
Dec 23, 2011·The Journal of Physical Chemistry. B·Margarita ValeroCécile A Dreiss
Sep 3, 2013·The Journal of Physical Chemistry. B·Prabhat K Singh, Sukhendu Nath
Jul 30, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alessandro TorchioGianluca Ciardelli
Feb 17, 2021·Advances in Colloid and Interface Science·Larissa Dos Santos Silva AraújoLeonardo Chiappisi
Aug 14, 2010·The Journal of Physical Chemistry. B·Andrés Guerrero-MartínezGloria Tardajos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.