Copolymer Networks From Oligo(ε-caprolactone) and n-Butyl Acrylate Enable a Reversible Bidirectional Shape-Memory Effect at Human Body Temperature

Macromolecular Rapid Communications
Mersa SaatchiAndreas Lendlein

Abstract

Exploiting the tremendous potential of the recently discovered reversible bidirectional shape-memory effect (rbSME) for biomedical applications requires switching temperatures in the physiological range. The recent strategy is based on the reduction of the melting temperature range (ΔT m ) of the actuating oligo(ε-caprolactone) (OCL) domains in copolymer networks from OCL and n-butyl acrylate (BA), where the reversible effect can be adjusted to the human body temperature. In addition, it is investigated whether an rbSME in the temperature range close or even above Tm,offset (end of the melting transition) can be obtained. Two series of networks having mixtures of OCLs reveal broad ΔTm s from 2 °C to 50 °C and from -10 °C to 37 °C, respectively. In cyclic, thermomechanical experiments the rbSME can be tailored to display pronounced actuation in a temperature interval between 20 °C and 37 °C. In this way, the application spectrum of the rbSME can be extended to biomedical applications.

References

Jun 15, 2013·Advanced Materials·Marc BehlAndreas Lendlein
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Marc BehlAndreas Lendlein
Apr 16, 2014·Advanced Materials·Jonathan ReederTakao Someya
Sep 12, 2013·Materials·Abdul BasitBernard Durand

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Citations

Jun 6, 2016·Advanced Drug Delivery Reviews·Maria BalkAndreas Lendlein
Oct 25, 2016·Macromolecular Rapid Communications·Lindsay N WoodardMelissa A Grunlan
Dec 6, 2016·Macromolecular Rapid Communications·Matt ZarekDaniel Cohn
Dec 20, 2016·ACS Applied Materials & Interfaces·Leonid IonovJens Uwe Sommer
Jan 17, 2017·ACS Applied Materials & Interfaces·Yuan GaoShiping Zhu
Mar 5, 2019·Advanced Healthcare Materials·Daniel CohnRaju Ramanujan
Jan 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Zijun DengAndreas Lendlein
Sep 19, 2019·Biomacromolecules·Andreas LendleinOliver E C Gould

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