Copper and liver function indicators vary depending on the female hormonal cycle and serum hormone binding globulin (SHBG) concentration in healthy women

Biological Trace Element Research
Mariana AyalaMagdalena Araya

Abstract

Previous studies showed that responses to chronic administration of copper were significantly associated with gender, raising the need to better characterize the relation between the effects observed and stradiols. The objective of this study was to measure copper and liver function indicators and the sex hormone binding globulin (SHBG) serum concentrations in healthy adults exposed to copper, grouped by sex and phase of the female hormonal cycle. Healthy females on day 7 (follicular phase, Group 1, n = 39), on day 21 (secretory phase, Group 2, n = 34) and males (comparison group, Group 3, n = 34) received 8 mg Cu/day (as copper sulfate), orally, for 6 months. On days 0, 30, 60, 120, and 180, the serum concentration of copper, ceruloplasmin, liver aminotransferases, and SHBG were measured. Analysis of results included analysis of variance (ANOVA; repeated measures) and the post hoc Bonferroni correction. Participants remained healthy throughout the study period, including aminotransferases below the cut off in all measures. GGT, AST, and ALT activities were significantly different by group and by time (ANOVA repeated measures P < 0.05). Six-month curves of serum copper and ceruloplasmin concentrations were different by group, b...Continue Reading

References

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May 26, 2004·The American Journal of Clinical Nutrition·Judith R TurnlundJames Coulter
Jul 9, 2004·Environmental Health Perspectives·Magdalena ArayaRicardo Uauy
Dec 8, 2004·Environmental Health Perspectives·Marco A MéndezMauricio González
Apr 9, 2005·The American Journal of Clinical Nutrition·Judith R TurnlundJoseph M Domek

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Citations

Apr 11, 2021·Biological Trace Element Research·Lyudmila V Bel'skayaVictor K Kosenok

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