Copper-Catalyzed Denitrogenative Transannulation Reaction of Pyridotriazoles: Synthesis of Imidazo[1,5-a]pyridines with Amines and Amino Acids

Organic Letters
Abhisek JoshiSubbarayappa Adimurthy

Abstract

The copper-catalyzed aerobic oxidative synthesis of imidazo[1,5-a]pyridines via cascade denitrogenative transannulation reaction of pyridotriazoles with benzylamines with good functional group tolerance is developed. The present methodology is also applicable to amino acids to obtain imidazo[1,5-a]pyridines via decarboxylative oxidative cyclization.

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Citations

Apr 26, 2016·The Journal of Organic Chemistry·Zhong LiShi-Tang Ma
Sep 30, 2016·The Journal of Organic Chemistry·Abhisek JoshiSubbarayappa Adimurthy
Jul 29, 2017·The Journal of Organic Chemistry·Jia-Chen XiangAn-Xin Wu
Mar 15, 2018·Angewandte Chemie·Takayuki NakamuroMasahiro Murakami
Jul 25, 2018·Organic & Biomolecular Chemistry·Zhiyuan HuJunbiao Chang

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