Copper-catalyzed direct alkylation of heteroarenes

Chemical Science
Cédric TheunissenGwilherm Evano

Abstract

An efficient and broadly applicable process is reported for the direct alkylation of C-H bonds in heteroarenes, privileged scaffolds in many areas of science. This reaction is based on the copper-catalyzed addition of alkyl radicals generated from activated secondary and tertiary alkyl bromides to a wide range of arenes, including furans, thiophenes, pyrroles, and their benzo-fused derivatives, as well as coumarins and quinolinones.

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Citations

Jun 10, 2017·Organic Letters·Bastien MicheletGwilherm Evano
Aug 15, 2018·Angewandte Chemie·Gwilherm Evano, Cédric Theunissen
Jul 17, 2020·Chemical Communications : Chem Comm·Lixin LiYan-Na Ma
Apr 3, 2020·Chemical Communications : Chem Comm·Zhiqiang PanChengfeng Xia
Nov 10, 2018·The Journal of Organic Chemistry·Pierre ThilmanyGwilherm Evano
May 28, 2019·The Journal of Organic Chemistry·José María Muñoz-Molina, Pedro J Pérez
Nov 15, 2017·Organic Letters·Antoine NiteletGwilherm Evano
Nov 12, 2020·The Journal of Organic Chemistry·Shaoqun ZhuHong Hou
Nov 30, 2021·Chemistry : a European Journal·Hajar Baguia, Gwilherm Evano

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