Copper-Catalyzed Geminal Difunctionalization of Terminal Alkynes by Splitting Sulfonyl Hydrazones into Two Parts

Organic Letters
Qi SunZhiyong Wang

Abstract

A copper(I)-catalyzed geminal difunctionalization of terminal alkynes was developed via a carbene migratory insertion and an addition of a sulfonyl anion to the triple bond at the same time under mild reaction conditions, providing a variety of vinyl sulfones with good yields and excellent stereoselectivities.

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Citations

Oct 28, 2019·Chemical Communications : Chem Comm·Yunhe LvMengxing Cui
Nov 20, 2019·Angewandte Chemie·Ruben MartinYangyang Shen
Feb 11, 2020·Organic & Biomolecular Chemistry·Aaran J FlynnAnita R Maguire
Sep 26, 2020·Chemical Communications : Chem Comm·Yunhe LvXiaoxing Wang

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