Copper-Catalyzed Insertion into Heteroatom-Hydrogen Bonds with Trifluorodiazoalkanes

Angewandte Chemie
Stephen HydeVéronique Gouverneur

Abstract

Copper-catalyzed Si-H, B-H, P-H, S-H, and N-H insertion reactions of 2,2,2-trifluoro-1-diazoethane and 1-aryl 2,2,2-trifluorodiazoethanes generated a large number of new fluorine-containing chemical entities for medicinal chemists. With selected Si-H and B-H insertion reactions, we demonstrate successful extension to asymmetric catalysis.

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Citations

Aug 2, 2016·The Journal of Organic Chemistry·Shouxiong ChenZhiqiang Weng
Jan 6, 2017·The Journal of Organic Chemistry·Zhong-Quan Liu, Dong Liu
Feb 15, 2017·Journal of the American Chemical Society·Ji-Min YangQi-Lin Zhou
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