Copper-Catalyzed Intermolecular Carboamination of Alkenes Induced by Visible Light

Organic Letters
Yang XiongGuozhu Zhang

Abstract

A photoinduced copper-catalyzed three-component reaction involving carbohalide, alkene and amine has been developed, leading to valuable fluoroalkyl-containing amines. A sole inexpensive CuCl is used as the photo- and coupling catalyst. A broad array of substrates are capable coupling partners. The diverse method is compatible with a broad range of functional groups and can be further applied to the late-stage functionalization of bioactive pharmaceuticals.

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Citations

May 23, 2019·Angewandte Chemie·Dirk Leifert, Armido Studer
Feb 15, 2020·Chemical Society Reviews·Heng Jiang, Armido Studer
May 28, 2020·Chemical Society Reviews·Li-Jie Cheng, Neal P Mankad

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