Copper-Catalyzed Ligand-Free Diazidation of Olefins with TMSN3 in CH3 CN or in H2 O

Organic Letters
Huan ZhouHongli Bao

Abstract

An environmentally benign, copper-catalyzed diazidation of a broad range of olefins, including vinylarenes, unactivated alkenes, allene, and dienes, under mild conditions with TMSN3 (trimethylazidosilane) as azido source, has been developed. This reaction can be carried out in organic solvent or in aqueous solution where water is the sole solvent. The functional group compatibility of this reaction is good, which is proved by late-stage functionalizations of complex substrates.

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Citations

Nov 15, 2018·Chemical Communications : Chem Comm·Ngoc-Minh PhanDarren W Johnson
Feb 7, 2019·Chemical Communications : Chem Comm·Jian ChenLingling Chu
Feb 16, 2019·Chemical Communications : Chem Comm·Thurpu Raghavender ReddySudhir Kashyap

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