Copper-Catalyzed One-Pot N-Acylation and C5-H Halogenation of 8-Aminoquinolines: The Dual Role of Acyl Halides

The Journal of Organic Chemistry
Yi DuaJie-Ping Wan

Abstract

The synthesis of N-acyl-5-halo-8-aminoquinolines has been realized by directly employing 8-aminoquinolines and acyl halides (Cl, Br, I) with copper catalysis. The construction of the target products involves domino N-acylation and C5-H halogenations of the 8-aminoquinoline, wherein the acyl halides act as the donors of both acyl and halide atoms, which enables the first access to the step efficient synthesis of 5-halogenated N-acyl quinlolines.

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Citations

Jun 12, 2020·Topics in Current Chemistry·Zhihui XuRenhua Qiu
Aug 7, 2018·The Journal of Organic Chemistry·Qing YuYunyun Liu
Aug 11, 2018·The Journal of Organic Chemistry·Susmita Mondal, Alakananda Hajra

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